A nitric oxide donor
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Product Categories

Product Type

Biochemicals
Nitric Oxide Donors

Research Area

FK-409

Item No. 82290

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-ethyl-2E-(hydroxyimino)-5-nitro-3E-hexenamide
CAS Number
138472-01-2
Synonyms
  • NOR-3
Molecular Formula
C8H13N3O4
Formula Weight
215.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: >34 mg/mlDMSO: >20 mg/mlEthanol: >36 mg/mlPBS pH 7.2: >2.2 mg/ml
SMILES
CC/C(=C\C(=N\O)/C(=O)N)/C(C)[N+](=O)[O-]
InChi Code
InChI=1S/C8H13N3O4/c1-3-6(5(2)11(14)15)4-7(10-13)8(9)12/h4-5,13H,3H2,1-2H3,(H2,9,12)/b6-4+,10-7+
InChi Key
MZAGXDHQGXUDDX-AGLLBGTNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $22

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    5 mg

    $94

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    10 mg

    $161

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    50 mg

    $702

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    Product Description

    FK-409 is a NO donor. It liberates NO in a time-dependent manner with a half-life of approximately 40 minutes in phosphate buffer (pH 7.4) at 37°C.1 The IC50 for the inhibition of platelet aggregation is 4.9 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kita, Y., Hirasawa, Y., Maeda, K., et al. Spontaneous nitric oxide release accounts for the potent pharmacological actions of FK409. Eur. J. Pharmacol. 257(1-2), 123-130 (1994).

    2. Fukuyama, S., Hirasawa, Y., Kato, Y., et al. Structure-activity relationships of spontaneous nitric oxide releasers, FK409 and its derivatives. J. Pharmacol. Exp. Ther. 282(1), 236-242 (1997).