A nitric oxide donor intended for in vivo use
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SE 175

Item No. 82340

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-[(nitrooxy)methyl]benzoyl]thio]-benzoic acid, methyl ester
CAS Number
258278-64-7
Molecular Formula
C16H13NO6S
Formula Weight
347.3
Purity
≥97%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMF:PBS (1:9): 100 µg/mlDMSO: 35 mg/mlEthanol: 11 mg/ml
λmax
205, 243, 278 nm
SMILES
COC(=O)c1ccccc1SC(=O)c1ccc(CO[N](=O)O)cc1
InChi Code
InChI=1S/C16H13NO6S/c1-22-15(18)13-4-2-3-5-14(13)24-16(19)12-8-6-11(7-9-12)10-23-17(20)21/h2-9H,10H2,1H3
InChi Key
JDIVRBDMTYQVOK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $65

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    10 mg

    $119

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    50 mg

    $493

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    100 mg

    $862

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    Product Description

    SE 175 is an organic nitrate compound of the same general class as nitroglycerin. These nitrate compounds can act as NO-donors in vivo following reductive transformation of the nitrate group to nitric oxide. The nitroxyacylated thiosalicylates, such as SE 175, were developed in an effort to facilitate this reductive process and accelerate the release of NO. SE 175 is stable in buffer or saline solution. In the intact rat, it stimulates endothelial soluble guanylate cyclase and induces aortic vasorelaxation with an EC50 of 20 µM, which is intermediate in potency between nitroglycerine and isosorbide dinitrate.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Endres, S., Hacker, A., Noack, E., et al. NO-donors, Part 3: Nitrooxyacylated thiosalicylates and salicylates-synthesis and biological activities. Eur. J. Med. Chem. 34, 895-901 (1999).