A hypoxic cell marker
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Product Categories

Product Type

Biochemicals
Labeling & Detection

Research Area

Cancer
Tumor Microenvironment

Pimonidazole

Item No. 89130

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-[(2-nitro-1H-imidazol-1-yl)methyl]-1-piperidineethanol
CAS Number
70132-50-2
Synonyms
  • NSC 380540
  • Ro 03-8799
Molecular Formula
C11H18N4O3
Formula Weight
254.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 0.15 mg/ml
λmax
202, 316 nm
SMILES
OC(CN1CCCCC1)CN2C([N+]([O-])=O)=NC=C2
InChi Code
InChI=1S/C11H18N4O3/c16-10(8-13-5-2-1-3-6-13)9-14-7-4-12-11(14)15(17)18/h4,7,10,16H,1-3,5-6,8-9H2
InChi Key
WVWOOAYQYLJEFD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $68

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    50 mg

    $268

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    100 mg

    $469

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    Cayman Chemical
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    Product Description

    Hypoxic cells are low oxygen cells that when present in tumors are radioresistant and chemoresistant. Pimonidazole is a small molecule radiosensitizer that has proven to be an effective and nontoxic hypoxia marker for human squamous cell carcinomas of the cervix, head, and neck.1 This immunochemical hypoxia marker has been widely used in experimental and clinical studies due to its chemical stability, water solubility, and wide tissue distribution. It is generally administered in aqueous solution by injection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kaanders, J.H.A.M., Wijffels, K.I.E.M., Marres, H.A.M., et al. Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer. Cancer Res. 62(23), 7066-7074 (2002).