An oxidized nucleoside and a marker of RNA oxidative damage
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8-Hydroxyguanosine

Item No. 89300

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7,8-dihydro-8-oxo-guanosine
CAS Number
3868-31-3
Synonyms
  • 7,8-Dihydro-8-oxoguanosine
  • 8-oxo-G
  • NSC 90393
  • 8-OHG
Molecular Formula
C10H13N5O6
Formula Weight
299.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.1 M HCl: 10 mg/mlDMF: Slightly solubleDMSO: 10 mg/mlEthanol: Sligthly soluble
λmax
250, 296 nm
SMILES
NC(N1[H])=NC(N([C@H]2[C@H](O)[C@H](O)[C@@H](CO)O2)C(O)=N3)=C3C1=O
InChi Code
InChI=1S/C10H13N5O6/c11-9-13-6-3(7(19)14-9)12-10(20)15(6)8-5(18)4(17)2(1-16)21-8/h2,4-5,8,16-18H,1H2,(H,12,20)(H3,11,13,14,19)/t2-,4-,5-,8-/m1/s1
InChi Key
FPGSEBKFEJEOSA-UMMCILCDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    8-Hydroxyguanosine is an oxidized nucleoside and a marker of RNA oxidative damage.1 Levels of 8-hydroxyguanosine increase in HeLa cells in a concentration-dependent manner when cultured with hydrogen peroxide. It has been detected in neurons in postmortem brain from patients with Alzheimer's or Parkinson's disease.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, J., and Li, Z. Human polynucleotide phosphorylase reduces oxidative RNA damage and protects HeLa cell against oxidative stress. Biochem. Biophys. Res. Commun. 372(2), 288-292 (2008).

    2. Nunomura, A., Perry, G., Pappolla, M.A., et al. RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer’s disease. J. Neurosci. 19(6), 1959-1964 (1999).

    3. Zhang, J., Perry, G., Smith, M.A., et al. Parkinson’s disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. Am. J. Pathol. 154(5), 1423-1429 (1999).