Product of oxidative damage to DNA
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8-Hydroxy-2'-deoxyguanosine

Item No. 89320

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2'-deoxy-7,8-dihydro-8-oxo-guanosine
CAS Number
88847-89-6
Synonyms
  • 7,8-dihydro-8-oxo-2'-Deoxyguanosine
  • 8-oxo-2'-Deoxyguanosine
  • 8-oxo-7,8-dihydro-2'-Deoxyguanosine
  • 8-oxo-dG
  • 8-Hydroxydeoxyguanosine
  • 8-Oxodeoxyguanosine
Molecular Formula
C10H13N5O5
Formula Weight
283.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.1 M HCl: >10 mg/mlDMF: 30 mg/mlDMSO: 20 mg/mlPBS pH 7.2: 3 mg/ml
λmax
249, 296 nm
SMILES
NC(N1[H])=NC(N([C@H]2C[C@H](O)[C@@H](CO)O2)C(N3)=O)=C3C1=O
InChi Code
InChI=1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1
InChi Key
HCAJQHYUCKICQH-VPENINKCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $31

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    5 mg

    $124

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    10 mg

    $185

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    25 mg

    $347

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    Product Description

    8-Hydroxy-2'-deoxyguanosine is produced by oxidative damage of DNA by reactive oxygen and nitrogen species, including hydroxyl radical and peroxynitrite. It serves as a measure of oxidative stress in biological systems.1,2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Floyd, R.A. Role of oxygen free radicals in carcinogenesis and brain ischemia. The FASEB Journal 4(9), 2587-2597 (1990).

    2. Beckman, K.B., and Ames, B.N. Oxidative decay of DNA. The Journal of Biological Chemisty 272(32), 19633-19636 (1997).

    3. Spencer, J.P.E., Jenner, A., Chimel, K., et al. DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett. 374(2), 233-236 (1995).

    4. Epe, B., Ballmaier, D., Roussyn, I., et al. DNA damage by peroxynitrite characterized with DNA repair enzymes. Nucleic Acids Res. 24(21), 4105-4110 (1996).