Product of oxidative damage to DNA
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Hydroxymethyl Uracil

Item No. 89360

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(hydroxymethyl)-2,4(1H,3H)-pyrimidinedione
CAS Number
4433-40-3
Molecular Formula
C5H6N2O3
Formula Weight
142.1
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 60 mg/mlDMSO: 53 mg/mlEthanol: 0.8 mg/mlPBS (7.2): 8 mg/ml
λmax
263 nm
SMILES
O=C(N1[H])C(CO)=CN([H])C1=O
InChi Code
InChI=1S/C5H6N2O3/c8-2-3-1-6-5(10)7-4(3)9/h1,8H,2H2,(H2,6,7,9,10)
InChi Key
JDBGXEHEIRGOBU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    250 mg

    $14

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    1 g

    $41

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    5 g

    $173

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    10 g

    $302

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    Product Description

    Hydroxymethyl uracil is a product of oxidative damage to DNA, predominantly by hydroxyl radical via the Fenton reaction.1,2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zastawny, T.H., Altman, S.A., Randers-Eichhorn, L., et al. DNA base modifications and membrane damage in cultured mammalian cells treated with iron ions. Free Radic. Biol. Med. 18, 1013-1022 (1995).

    2. Spencer, J.P.E., Jenner, A., Chimel, K., et al. DNA strand breakage and base modification induced by hydrogen peroxide treatment of human respiratory tract epithelial cells. FEBS Lett. 374(2), 233-236 (1995).

    3. Jaruga, P., Zastawny, T.H., Skokowski, J., et al. Oxidative DNA base damage and antioxidant enzyme activities in human lung cancer. FEBS Lett. 341, 59-64 (1994).