An inhibitor of cholesteryl ester transfer protein
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Dalcetrapib

Item No. 89450

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
S-[2-[[[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino]phenyl]propanethioic acid, 2-methyl ester
CAS Number
211513-37-0
Synonyms
  • JTT-705
Molecular Formula
C23H35NO2S
Formula Weight
389.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/mlEthanol:PBS ( 7.2 pH) (1:1): 1 mg/ml
SMILES
[H]N(C1=C(SC(C(C)C)=O)C=CC=C1)C(C2(CC(CC)CC)CCCCC2)=O
InChi Code
InChI=1S/C23H35NO2S/c1-5-18(6-2)16-23(14-10-7-11-15-23)22(26)24-19-12-8-9-13-20(19)27-21(25)17(3)4/h8-9,12-13,17-18H,5-7,10-11,14-16H2,1-4H3,(H,24,26)
InChi Key
YZQLWPMZQVHJED-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $43

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    5 mg

    $161

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    10 mg

    $301

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    25 mg

    $537

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    Product Description

    Dalcetrapib is an inhibitor of CETP that exhibits an IC50 value of 9 µM for plasma CETP in rabbits.1 Inhibition of CETP by dalcetrapib in rabbits given an atherogenic diet leads to elevation of HDL, decreased VLDL, and attenuation of the induced atherosclerosis.1 In human subjects, dalcetrapib also inhibits CETP activity and increases plasma HDL levels but it does not reduce the risk of recurrent cardiovascular events.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Okamoto, H., Yonemori, F., Wakitani, K., et al. A cholesteryl ester transfer protein inhibitor attenuates atherosclerosis in rabbits. Nature 406, 203-206 (2000).

    2. Rader, D.J. Molecular regulation of HDL metabolism and function: implications for novel therapies. J. Clin. Invest. 116(12), 3090-3100 (2006).

    3. Schwartz, G.G., Olsson, A.G., Abt, M., et al. Effects of dalcetrapib in patients with a recent acute coronary syndrome. N. Engl. J. Med. 367(22), 2089-2099 (2012).