An inhibitor of the PLA2 activity of Prdx6
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MJ33 (lithium salt)

Item No. 90001844

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
phosphoric acid, mono[1-[(hexadecyloxy)methyl]-2-(2,2,2-trifluoroethoxy)ethyl] monomethyl ester, monolithium salt
CAS Number
1007476-63-2
Molecular Formula
C22H43F3O6P • Li
Formula Weight
498.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/mlDMSO: 0.25 mg/mlEthanol: 2 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
SMILES
O=P(OC)([O-])OC(COCC(F)(F)F)COCCCCCCCCCCCCCCCC.[Li+]
InChi Code
InChI=1S/C22H44F3O6P.Li/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-29-18-21(31-32(26,27)28-2)19-30-20-22(23,24)25;/h21H,3-20H2,1-2H3,(H,26,27);/q;+1/p-1
InChi Key
GDLMLQJISATCEL-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

    $126

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    10 mg

    $231

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    25 mg

    $530

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    Product Description

    MJ33 is a selective, reversible inhibitor of the acidic, calcium-independent (ai)PLA2 activity of Prdx6, with optimal inhibition achieved at an MJ33 concentration of 3 mol%.1,2,3 It blocks the degradation of DPPC in both whole lung and isolated alveolar type II epithelial cells.4 MJ33 has been used to examine the role of Prdx6 PLA2 activity in the activation of type 2 NADPH oxidase and in the regulation of Prdx6 PLA2 activity by phosphorylation.5,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fisher, A.B., and Dodia, C. Role of phospholipase A2 enzymes in degradation of dipalmitoylphosphatidylcholine by granular pneumocytes. J. Lipid Res. 37, 1057-1064 (1996).

    2. Kim, T.S., Sundaresh, C.S., Feinstein, S.I., et al. Identification of a human cDNA clone for lysosomal type Ca2+-independent phospholipase A2 and properties of the expressed protein. The Journal of Biological Chemisty 272, 2542-2550 (1997).

    3. Fisher, A.B., Dodia, C., Chander, A., et al. A competitive inhibitor of phospholipase A2 decreases surfactant phosphatidylcholine degradation by the rat lung. Biochem. J. 288(Pt 2), 407-411 (1992).

    4. Fisher, A.B., Dodia, C., Feinstein, S.I., et al. Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A2. J. Lipid Res. 46(6), 1248-1256 (2005).

    5. Lee, I., Dodia, C., Chatterjee, S., et al. Protection against LPS-induced acute lung injury by a mechanism-based inhibitor of NADPH oxidase (type 2). Am. J. Physiol. Lung Cell. Mol. Physiol. 306, L635-L644 (2014).

    6. Wu, Y., Feinstein, S.I., Manevich, Y., et al. Mitogen-activated protein kinase-mediated phosphorylation of peroxiredoxin 6 regulates its phospholipase A2 activity. Biochem. 419(3), 669-679 (2009).