A re-activator of the apoptotic function of mutant p53 proteins
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PRIMA-1MET

Item No. 9000487

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one
CAS Number
5291-32-7
Synonyms
  • APR 246
Molecular Formula
C10H17NO3
Formula Weight
199.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 25 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
O=C1C2CCN(CC2)C1(CO)COC
InChi Code
InChI=1S/C10H17NO3/c1-14-7-10(6-12)9(13)8-2-4-11(10)5-3-8/h8,12H,2-7H2,1H3
InChi Key
BGBNULCRKBVAKL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $75

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    10 mg

    $120

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    25 mg

    $241

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    50 mg

    $442

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    Cayman Chemical
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    Product Description

    PRIMA-1MET is a methylated derivative of PRIMA-1 that restores tumor-suppressor function to mutant p53 and induces cell death in various cancer cell lines.1 PRIMA-1MET can synergize with chemotherapeutic drugs to induce tumor cell apoptosis.2 At 25-50 µM, it can also dose-dependently inhibit thioredoxin reductase, a key regulator of cellular redox balance.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aryee, D.N., Niedan, S., Ban, J., et al. Variability in functional p53 reactivation by PRIMA-1Met/APR-246 in Ewing sarcoma. Br. J. Cancer 109(10), 2696-2704 (2013).

    2. Bykov, V.J., Zache, N., Stridh, H., et al. PRIMA-1MET synergizes with cisplatin to induce tumor cell apoptosis. Oncogene 24(21), 3484-3491 (2005).

    3. Peng, X., Zhang, M.Q., Conserva, F., et al. APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase. Cell Death Dis. 4(10), e881 (2013).