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hydroxy Bupropion

Item No. 9000522

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • BUPOH
  • OH-bupropion
Technical Information
Formal Name
2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol
CAS Number
357399-43-0
Molecular Formula
C13H18ClNO2
Formula Weight
255.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.50 mg/ml
SMILES
CC1NC(C)(C)COC1(C2=CC=CC(Cl)=C2)O
InChi Code
InChI=1S/C13H18ClNO2/c1-9-13(16,17-8-12(2,3)15-9)10-5-4-6-11(14)7-10/h4-7,9,15-16H,8H2,1-3H3
InChi Key
RCOBKSKAZMVBHT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    hydroxy Bupropion (Item No. 9000522) is an analytical reference standard categorized as an antidepressant.1 hydroxy Bupropion is a metabolite of bupropion (Item No. 10488).2 It substitutes for (+)-amphetamine (D-amphetamine; Item No. 26204) in rats in a two-lever drug discrimination test.3 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1.  Antidepressants: From biogenic amines to new mechanisms of action. 250, (2018).

    2. Coles, R., and Kharasch, E.D. Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes. Pharm. Res. 25(6), 1405-1411 (2008).

    3. Bondarev, M.L., Bondareva, T.S., Young, R., et al. Behavioral and biochemical investigations of bupropion metabolites. Eur. J. Pharmacol. 474(1), 85-93 (2003).