An antiarrhythmic agent
Related Products
Active Metabolite(s)
34888N-Desbutyl Dronedarone (hydrochloride)
Labeled Version(s)
31787Dronedarone-d6 (hydrochloride)
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Product Categories

Product Type

Biochemicals

Research Area

Cardiovascular System
Heart
Arrhythmia

Dronedarone (hydrochloride)

Item No. 9000543

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]-methanesulfonamide, monohydrochloride
CAS Number
141625-93-6
Synonyms
  • SR33589
Molecular Formula
C31H44N2O5S • HCl
Formula Weight
593.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 5 mg/ml
λmax
219, 251, 288 nm
SMILES
CCCCC1=C(C(C2=CC=C(OCCCN(CCCC)CCCC)C=C2)=O)C3=CC(NS(C)(=O)=O)=CC=C3O1.Cl
InChi Code
InChI=1S/C31H44N2O5S.ClH/c1-5-8-12-29-30(27-23-25(32-39(4,35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3;/h13-18,23,32H,5-12,19-22H2,1-4H3;1H
InChi Key
DWKVCQXJYURSIQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $49

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    50 mg

    $190

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    100 mg

    $329

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    250 mg

    $702

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    Product Description

    Dronedarone is an antiarrhythmic agent and a derivative of amiodarone (Item No. 15213).1,2 It inhibits muscarinic acetylcholine receptor-dependent potassium currents induced by carbachol (carbamoylcholine; Item No. 14486) or intracellular loading of GTPγS in single cells isolated from guinea pig atria (IC50s = 0.1 and 1 µM, respectively).2 Dronedarone (50 and 100 mg/kg) reduces sinus frequency and prolongs action potential duration (APD) in isolated rabbit ventricular myocardium. It increases atrial APD and the atrial effective refractory period (AERP) in a dog model of atrial fibrillation induced by rapid right atrial pacing.3 Formulations containing dronedarone have been used in the treatment of atrial fibrillation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sun, W., Sarma, J.S., and Singh, B.N. Electrophysiological effects of dronedarone (SR33589), a noniodinated benzofuran derivative, in the rabbit heart: Comparison with amiodarone. Circulation 100(22), 2276-2281 (1999).

    2. Guillemare, E., Marion, A., Nisato, D., et al. Inhibitory effects of dronedarone on muscarinic K+ current in guinea pig atrial cells. J. Cardiovasc. Pharmacol. 36(6), 802-805 (2000).

    3. Saengklub, N., Limprasutr, V., Sawangkoon, S., et al. Dronedarone attenuates the duration of atrial fibrillation in a dog model of sustained atrial fibrillation. Exp. Anim. 66(3), 251-258 (2017).