Intermediate in the synthesis of CRTH2/DP2 antagonists
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CAY10648

Item No. 9000549

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-2,2'-dioxo-1,1-dimethylethyl ester-spiro[3H-indole-3,3'-pyrrolidine]-1(2H)-acetic acid
CAS Number
916048-02-7
Molecular Formula
C17H19ClN2O4
Formula Weight
350.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.25 mg/mlEthanol: 1 mg/ml
SMILES
ClC1=CC=C(N(C(C23CCNC3=O)=O)CC(OC(C)(C)C)=O)C2=C1
InChi Code
InChI=1S/C17H19ClN2O4/c1-16(2,3)24-13(21)9-20-12-5-4-10(18)8-11(12)17(15(20)23)6-7-19-14(17)22/h4-5,8H,6-7,9H2,1-3H3,(H,19,22)
InChi Key
FXDFCQKNBUKFLH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $81

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    5 mg

    $357

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    10 mg

    $633

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    Product Description

    CAY10648 is an intermediate used in the synthesis of potent DP2 receptor antagonists based on a novel spiro-indolinone compound.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Crosignani, S., Page, P., Missotten, M., et al. Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases. J. Med. Chem. 51(7), 2227-2243 (2008).