A neuroprotective agent
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Alternative(s)
10011349Dimebolin (hydrochloride)
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Dimebolin

Item No. 9000556

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,4,5-tetrahydro-2,8-dimethyl-5-[2-(6-methyl-3-pyridinyl)ethyl]-1H-pyrido[4,3-b]indole
CAS Number
3613-73-8
Synonyms
  • Dimebon™
  • Latrepirdine
Molecular Formula
C21H25N3
Formula Weight
319.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 1 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
SMILES
CC1=CC=C(N(CCC2=CC=C(C)N=C2)C3=C4CN(C)CC3)C4=C1
InChi Code
InChI=1S/C21H25N3/c1-15-4-7-20-18(12-15)19-14-23(3)10-9-21(19)24(20)11-8-17-6-5-16(2)22-13-17/h4-7,12-13H,8-11,14H2,1-3H3
InChi Key
JNODQFNWMXFMEV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $24

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    5 mg

    $98

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    10 mg

    $173

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    25 mg

    $376

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    Product Description

    Dimebolin is a neuroprotective agent.1,2,3 It binds to histamine H1 and H2 receptors (IC50s = 3.8 and 287 nM, respectively), as well as α1A-, α1B-, α1D-, and α2A-adrenergic receptors (ARs), imidazoline I2 receptors, and the serotonin (5-HT) receptor subtypes 5-HT2A, 5-HT2C, 5-HT6, and 5-HT7 (Kis = 8-313 nM).4 It also inhibits NMDA-evoked currents and voltage-gated calcium channels in mouse primary striatal neurons (IC50s = 10 and 50 μM, respectively).1 Dimebolin (50 μM) inhibits glutamate-induced apoptosis in primary striatal neurons derived from the YAC128 transgenic mouse model of Huntington’s disease. It inhibits cell death induced by amyloid-β (25-35) (Item No. 24155) in cerebellar granule cells when used at a concentration of 25 μM.2 Dimebolin (1 mg/kg) inhibits decreases in two-way active avoidance reaction (TWAA) acquisition in a rat model of Alzheimer’s disease induced by 1-ethyl-1-(2-hydroxyethyl) aziridinium (AF64A).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, J., Li, Q., and Bezprozvanny, I. Evaluation of dimebon in cellular model of Huntington’s disease. Mol. Neurodegener. 3, 15 (2008).

    2. Lermontova, N.N., Redkozubov, A.E., Shevtsova, E.F., et al. Dimebon and tacrine inhibit neurotoxic action of β-amyloid in culture and block L-type Ca2+ channels. B. Exp. Biol. Med. 132(5), 1079-1083 (2001).

    3. Lermontova, N.N., Lukoyanov, N.V., Serkova, T.P., et al. Dimebon improves learning in animals with experimental Alzheimer’s disease. B. Exp. Biol. Med. 129(6), 640-642 (2000).

    4. Okun, I., Tkachenko, S.E., Khvat, A., et al. From anti-allergic to anti-Alzheimer’s: Molecular pharmacology of Dimebon™. Curr. Alzheimer Res. 7(2), 97-112 (2010).