A mixture of synthetic polypeptides that prevents MBP binding
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Glatiramer (acetate)

Item No. 9000571

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-glutamic acid, polymer with L-alanine, L-lysine, and L-tyrosine, acetate
CAS Number
147245-92-9
Synonyms
  • Copolymer 1
Molecular Formula
(C9H11NO3 • C6H14N2O2 • C5H9NO4 • C3H7NO2)x • XC2H4O2
Formula Weight
293.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 1 mg/ml
λmax
224, 278 nm
SMILES
OC(C)=O.OC1=CC=C(C[C@H](N)C(O)=O)C=C1.OC([C@@H](N)CCCCN)=O.OC(CC[C@H](N)C(O)=O)=O.OC([C@@H](N)C)=O
InChi Code
InChI=1S/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2.C2H4O2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6;1-2(3)4/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6);1H3,(H,3,4)/t8-;5-;3-;2-;/m0000./s1
InChi Key
FHEAIOHRHQGZPC-KIWGSFCNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    Product Description

    Glatiramer (acetate) is a mixture of synthetic polypeptides composed of four amino acids found in myelin basic protein (MBP): L-Alanine, L-glutamic acid, L-lysine, and L-tyrosine. It prevents MBP from binding to MHC class II molecules in the periphery and induces the production of immunomodulatory molecules considered to be anti-inflammatory.1 It also increases proliferation of oligodendrocyte and neuronal precursor cells in the central nervous system of mice.2,3 Formulations containing glatiramer (acetate) are used to treat patients with multiple sclerosis, particularly the relapsing-remitting type.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aharoni, R. The mechanism of action of glatiramer acetate in multiple sclerosis and beyond. Autoimmun. Rev. 12(5), 543-553 (2013).

    2. Skihar, V., Silva, C., Choinacki, A., et al. Promoting oligodendrogenesis and myelin repair using the multiple sclerosis medication glatiramer acetate. Proc. Natl. Acad. Sci. USA 106(42), 17992-17997 (2009).

    3. Aharoni, R., Arnon, R., and Eilam, R. Neurogenesis and neuroprotection induced by peripheral immunomodulatory treatment of experimental autoimmune encephalomyelitis. J. Neurosci. 25(36), 8217-8228 (2005).

    4. Ziemssen, T., Ashtamker, N., Rubinchik, S., et al. Long-term safety and tolerability of glatiramer acetate 20 mg/ml in the treatment of relapsing forms of multiple sclerosis. Expert Opin. Drug Discov. 16(2), 248-255 (2017).