An internal standard for the quantification of 2,3-dinor-11β-PGF2α
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Unlabeled Version(s)
165302,3-dinor-11β-Prostaglandin F2α
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2,3-dinor-11β-Prostaglandin F2α-d9

Item No. 9000603

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(Z)-5-((1R,2R,3S,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl-5,5,6,6,7,7,8,8,8-d9)cyclopentyl)pent-3-enoic acid
Synonyms
  • BPG-d9
  • 2,3-dinor-11β-PGF2α-d9
  • 2,3-dinor-11-epi PGF2α-d9
Molecular Formula
C18H21D9O5
Formula Weight
335.5
Purity
≥99% deuterated forms (d1-d9)
Formulation
A 250 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 100 mg/mlDMSO: 100 mg/mlEthanol: 100 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O[C@@H]1[C@H](C/C=C\CC(O)=O)[C@@H](/C=C/[C@@H](O)CC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])[C@@H](O)C1
InChi Code
InChI=1S/C18H30O5/c1-2-3-4-7-13(19)10-11-15-14(16(20)12-17(15)21)8-5-6-9-18(22)23/h5-6,10-11,13-17,19-21H,2-4,7-9,12H2,1H3,(H,22,23)/b6-5-,11-10+/t13-,14+,15+,16-,17-/m0/s1/i1D3,2D2,3D2,4D2
InChi Key
IDKLJIUIJUVJNR-RJGNUDNQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 µg

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    Product Description

    2,3-dinor-11β-PGF2α-d9 is intended for use as an internal standard for the quantification of 2,3-dinor-11β-PGF2α (Item No. 16530) by GC- or LC-MS. 2,3-dinor-11β-PGF2α is a metabolite of PGD2 (Item No. 12010).1,2 Urinary excretion of 2,3-dinor-11β-PGF2α is increased in patients with mast cell activation disease (MCAD) and has been used as a marker of increased PGD2 levels.3 2,3-dinor-11β-PGF2α levels are also increased in the urine of patients with asthma and are positively correlated with impaired lung function.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liston, T.E., and Roberts, L.J., II Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. The Journal of Biological Chemisty 260(24), 13172-13180 (1985).

    2. Song, W.L., Wang, M., Ricciotti, E., et al. Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans. The Journal of Biological Chemisty 283(2), 1179-1188 (2008).

    3. Castells, M., and Butterfield, J. Mast cell activation syndrome and mastocytosis: Initial treatment options and long-term management. J. Allergy Clin. Immunol. Pract. 7(4), 1097-1106 (2019).

    4. Kolmert, J., Gómez, C., Balgoma, D., et al. Urinary leukotriene E4 and prostaglandin D2 metabolites increase in adult and childhood severe asthma characterized by type 2 inflammation. A clinical observational study. Am. J. Respir. Crit. Care Med. 203(1), 37-53 (2021).