A potent, selective δ-opioid receptor antagonist
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Naltrindole (hydrochloride)

Item No. 9000705

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4bS,8R,8aS,14bR)-7-(cyclopropylmethyl)-5,6,7,8,14,14b-hexahydro-4,8-methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol, monohydrochloride
CAS Number
111469-81-9
Molecular Formula
C26H26N2O3 • HCl
Formula Weight
451.0
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 10 mg/mlEthanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
210, 284 nm
SMILES
O[C@]12[C@]3(CCN(CC4CC4)[C@@H]2C5)[C@](OC6=C3C5=CC=C6O)([H])C(NC7=C8C=CC=C7)=C8C1.Cl
InChi Code
InChI=1S/C26H26N2O3.ClH/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14;/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2;1H/t20-,24+,25+,26-;/m1./s1
InChi Key
KNJKRQXCFJCQHC-IDRHMUJXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Naltrindole is a potent antagonist of the human δ-opioid receptor (Ki = 0.02-0.3 nM), with much lower affinities for κ- and µ-opioid receptors (Kis = 10-66 and 6-64 nM, respectively).1,2 Naltrindole is commonly used to investigate the role of the δ-opioid receptor in signaling responses to test compounds.3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Meng, F., Wei, Q., Hoversten, M.T., et al. Switching agonist/antagonist properties of opitate alkaloids at the δ opioid receptor using mutations based on the structure of the orphanin FQ receptor. The Journal of Biological Chemisty 275(29), 21939-21945 (2000).

    2. Raynor, K., Kong, H., Chen, Y., et al. Pharmacological characterization of the cloned κ-, δ-, and μ-opioid receptors. Mol. Pharm. 45(2), 330-334 (1994).

    3. Steinmiller, C.L., and Young, A.M. Pharmacological selectivity of CTAP in a warm water tail-withdrawal antinociception assay in rats. Psychopharmacology (Berl) 195(4), 497-507 (2008).

    4. Shannon, H.E., and Lutz, E.A. Comparison of the peripheral and central effects of the opioid agonists loperamide and morphine in the formalin test in rats. Neuropharmacology 42(2), 253-261 (2002).

    5. Mendes, G.L., Santos, A.R.S., Malheiros, A., et al. Assessment of mechanisms involved in antinociception caused by sesquiterpene polygodial. J. Pharmacol. Exp. Ther. 292(1), 164-172 (2000).