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JWH 398 N-(5-hydroxypentyl) metabolite

Item No. 9000770

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4-chloro-1-naphthalenyl)[1-(5-hydroxypentyl)-1H-indol-3-yl]-methanone
CAS Number
1379604-69-9
Molecular Formula
C24H22ClNO2
Formula Weight
391.9
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 25 mg/mlEthanol: 15 mg/ml
λmax
219, 315 nm
SMILES
O=C(C1=CN(CCCCCO)C2=C1C=CC=C2)C3=C4C(C=CC=C4)=C(Cl)C=C3
InChi Code
InChI=1S/C24H22ClNO2/c25-22-13-12-20(17-8-2-3-9-18(17)22)24(28)21-16-26(14-6-1-7-15-27)23-11-5-4-10-19(21)23/h2-5,8-13,16,27H,1,6-7,14-15H2
InChi Key
CYMQEAJNLISWKK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    JWH 398 is a synthetic cannabinoid (CB) that activates both CB1 and CB2 receptors (Ki values of 2.3 and 2.8 nM, respectively).1 It has been reported to be an adulterant of herbal products.2,3 JWH 398 N-(5-hydroxypentyl) metabolite is a potential metabolite of JWH 398. Metabolism of structurally similar compounds leads to monohydroxylation of the N-alkyl chain, detectable in urine.4 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Huffman, J.W. Cannabimimetic indoles, pyrroles, and indenes: Structure-activity relationships and receptor interactions. The cannabinoid receptors 49-95 (2009).

    2. Kikura-Hanajiri, R., Uchiyama, N., and Goda, Y. Survey of current trends in the abuse of psychotropic substances and plants in Japan. Leg. Med. (Tokyo) 13(3), 109-115 (2011).

    3. Dresen, S., Ferreirós, N., Pütz, M., et al. Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds. J. Mass Spectrom. 45(10), 1186-1194 (2010).

    4. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine. Forensic Sci. Int. 200(1-3), 141-147 (2010).

    Product Citations

    Cho, B., Cho, H.S., Kim, J., et al. Simultaneous determination of synthetic cannabinoids and their metabolites in human hair using LC-MS/MS and application to human hair. Forensic Sci. Int. 306, 110058 (2020).