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JWH 018 N-(5-hydroxypentyl) metabolite

Item No. 9000855

Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[1-(5-hydroxypentyl)-1H-indol-3-yl]-1-naphthalenyl-methanone
CAS Number
335161-21-2
Molecular Formula
C24H23NO2
Formula Weight
357.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 20 mg/mlEthanol: 15 mg/ml
λmax
218, 316 nm
SMILES
O=C(C1=CN(CCCCCO)C2=C1C=CC=C2)C3=C4C(C=CC=C4)=CC=C3
InChi Code
InChI=1S/C24H23NO2/c26-16-7-1-6-15-25-17-22(20-12-4-5-14-23(20)25)24(27)21-13-8-10-18-9-2-3-11-19(18)21/h2-5,8-14,17,26H,1,6-7,15-16H2
InChi Key
UGHBAICDASCCIQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    JWH 018 N-(5-hydroxypentyl) metabolite (Item No. 9000855) is an analytical reference standard categorized as a synthetic cannabinoid.1 JWH 018 N-(5-hydroxypentyl) metabolite is an active metabolite of JWH 018 (Item Nos. 27973 | 10900 | 13169) and AM2201 (Item Nos. 27043 | 10707).2,3 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rajasekaran, M., Brents, L.K., Franks, L.N., et al. Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors. Toxicol. Appl. Pharmacol. 269(2), 100-108 (2013).

    2. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine. Forensic Sci. Int. 200(1-3), 141-147 (2010).

    3. Diao, X., and Huestis, M.A. New synthetic cannabinoids metabolism and strategies to best identify optimal marker metabolites. Front. Chem. 7, 109 (2019).

    Product Citations

    Aderorho, R., Lucas, S.W., and Chouinard, C.D. Separation and characterization of synthetic cannabinoid metabolite isomers using SLIM high-resolution ion mobility-tandem mass spectrometry (HRIM-MS/MS). J. Am. Soc. Mass Spectrom. Online ahead of print, (2024).

    Cho, B., Cho, H.S., Kim, J., et al. Simultaneous determination of synthetic cannabinoids and their metabolites in human hair using LC-MS/MS and application to human hair. Forensic Sci. Int. 306, 110058 (2020).

    Ong, R.S., Kappatos, D.C., Russell, S.G.G., et al. Simultaneous analysis of 29 synthetic cannabinoids and metabolites, amphetamines, and cannabinoids in human whole blood by liquid chromatography-tandem mass spectrometry - A New Zealand perspective of use in 2018. Drug. Test. Anal. 12(2), 195-214 (2020).

    Chimalakonda, K.C., Bratton, S.M., Le, V.-H., et al. Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases. Drug Metab. Dispos. 39(10), 1967-1976 (2011).