An Analytical Reference Standard
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Alternative(s)
11748JWH 018 N-pentanoic acid metabolite-d5
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JWH 018 N-pentanoic acid metabolite-d4

Item No. 9000867

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(1-naphthalenylcarbonyl)-1H-Indole-1-pentanoic-β,β,γ,γ-d4 acid
CAS Number
1320363-49-2
Molecular Formula
C24H17D4NO3
Formula Weight
375.5
Purity
≥99% deuterated forms (d1-d4)
Formulation
A 1 mg/ml solution in methanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 30 mg/ml
λmax
219, 247, 316 nm
SMILES
O=C(C1=CN(CC([2H])([2H])C([2H])([2H])CC(O)=O)C2=C1C=CC=C2)C3=C4C(C=CC=C4)=CC=C3
InChi Code
InChI=1S/C24H21NO3/c26-23(27)14-5-6-15-25-16-21(19-11-3-4-13-22(19)25)24(28)20-12-7-9-17-8-1-2-10-18(17)20/h1-4,7-13,16H,5-6,14-15H2,(H,26,27)/i5D2,6D2
InChi Key
BYIVGHIYNFQIJX-NZLXMSDQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    JWH 018 N-pentanoic acid metabolite-d4 (Item No. 9000867) is intended for use as an internal standard for the quantification of JWH 018 N-pentanoic acid metabolite (Item No. 9000856) by GC- or LC-MS. JWH 018 is a mildly selective agonist of the peripheral cannabinoid (CB2) receptor, derived from the aminoalkylindole WIN 55,212-2. The Ki values for binding central cannabinoid (CB1) and CB2 receptors are 9.0 and 2.94 nM, respectively, for a CB1:CB2 ratio of 3.06.1 JWH 018 is one of several synthetic CBs which have been included in smoking mixtures. JWH 018 N-pentanoic acid metabolite is a minor urinary metabolite of JWH 018, characterized by carboxylation of the N-alkyl chain.2 In urine samples, this metabolite is almost completely glucuronidated.2 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug Alcohol Depend. 60(2), 133-140 (2000).

    2. Sobolevsky, T., Prasolov, I., and Rodchenkov, G. Detection of JWH-018 metabolites in smoking mixture post-administration urine. Forensic Sci. Int. 200(1-3), 141-147 (2010).