A photoaffinity probe
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Progesterone-3-biotinyl Photoaffinity Probe

Item No. 9000891

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(3-(2-((((10R,13S,E)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-ylidene)amino)oxy)acetamido)propyl)-2-(2-(2-(2-(5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethoxy)ethoxy)ethoxy)-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzamide
Synonyms
  • P4
  • P4 Binding Probe
Molecular Formula
C51H71F3N8O9S
Formula Weight
1029.2
Purity
≥95% (mixture of isomers)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 1 mg/mlEthanol: 10 mg/ml
λmax
242 nm
SMILES
O=C1NC2C(CCCCC(NCCOCCOCCOC3=C(C(NCCCNC(CO/N=C4CC[C@@](C(CC[C@@]5(C)C6CCC5C(C)=O)C6CC7)(C)C7=C\4)=O)=O)C=CC(C8(N=N8)C(F)(F)F)=C3)=O)SCC2N1
InChi Code
InChI=1S/C51H71F3N8O9S/c1-31(63)37-13-14-38-35-11-9-32-27-34(15-17-48(32,2)39(35)16-18-49(37,38)3)60-71-29-44(65)55-19-6-20-57-46(66)36-12-10-33(50(61-62-50)51(52,53)54)28-41(36)70-26-25-69-24-23-68-22-21-56-43(64)8-5-4-7-42-45-40(30-72-42)58-47(67)5
InChi Key
MFRNVJFMJXGWKC-DVGWBYOFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $134

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    1 mg

    $253

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    5 mg

    $1,191

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    Product Description

    Progesterone 3-biotinyl photoaffinity probe consists of active progesterone, a diazirine-UV (312 nm)-sensitive moiety, and a biotin tag. When activated by light, it binds covalently to its target and, thus, can be used to detect and observe the interaction of progesterone with target proteins. This probe has been used to help characterize the role of the human sperm progesterone receptor in male fertility.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miller, M.R., Mannowetz, N., Iavarone, A.T., et al. Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone. Science 352(65285), 555-559 (2016).