Inhibitor of GABA transaminase
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Labeled Version(s)
26672Vigabatrin-13C-d2 (hydrochloride)
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Vigabatrin

Item No. 9000976

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-5-hexenoic acid
CAS Number
68506-86-5
Synonyms
  • γ-Vinyl GABA
Molecular Formula
C6H11NO2
Formula Weight
129.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
C=CC(CCC(O)=O)N
InChi Code
InChI=1S/C6H11NO2/c1-2-5(7)3-4-6(8)9/h2,5H,1,3-4,7H2,(H,8,9)
InChi Key
PJDFLNIOAUIZSL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    5 mg

    $49

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    10 mg

    $93

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    25 mg

    $213

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    50 mg

    $376

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    Product Description

    Vigabatrin is an irreversible GABA transaminase (GABA-T) inhibitor.1 It inhibits rat brain GABA-T when used at a concentration of 0.1 mM. Vigabatrin is selective for rat brain GABA-T over P. fluorescens GABA-T at 10 mM and is 100-fold selective over rat brain glutamic acid decarboxylase (GAD). Vigabatrin (1,500 mg/kg) decreases brain GABA-T activity without affecting GAD activity in mice.2 It reduces the incidence of myoclonus in a mouse model of audiogenic seizures.3 Vigabatrin also increases the electroconvulsive threshold in mouse model of maximal electroshock-induced seizures and reduces the number of clonic convulsions induced by pentylenetetrazol (PTZ; Item No. 18682) in mice.4 Formulations containing vigabatrin have been used in the treatment of seizures and infantile spasms.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lippert, B., Metcalf, B.W., Jung, M.J., et al. 4-Amino-hex-5-enoic acid, a selective catalytic inhibitor of 4-aminobutyric-acid aminotransferase in mammalian brain. Eur. J. Biochem. 74(3), 441-445 (1977).

    2. Jung, M.J., Lippert, B., Metcalf, B.W., et al. g-Vinyl GABA (4-amino-hex-5-enoic acid), A new selective irreversible inhibitor of GABA-T: Effects on brain GABA metabolism in mice. J. Neurochem. 29(5), 797-802 (1977).

    3. Meldrum, B.S., and Murugaiah, K. Anticonvulsant action in mice with sound-induced seizures of the optical isomers of g-vinyl GABA. Eur. J. Pharm. 89(1-2), 149-152 (1983).

    4. Luszczki, J.J., and Czuczwar, S.J. Isobolographic characterization of interactions between vigabatrin and tiagabine in two experimental models of epilepsy. Prog. Neuropsychopharmacol. Biol. Psychiatry 31(2), 529-538 (2007).