An alkaloid amide with anti-inflammatory properties
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Piperlonguminine

Item No. 9001155

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-2E,4E-pentadienamide
CAS Number
5950-12-9
Synonyms
  • N-Isobutylpiperamide
  • NSC 125178
Molecular Formula
C16H19NO3
Formula Weight
273.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:2): 5 mg/mlEthanol: 3 mg/mlPBS (pH 7.2): Insolublwe
λmax
242, 252, 308, 339 nm
SMILES
O=C(/C=C/C=C/C1=CC=C(OCO2)C2=C1)NCC(C)C
InChi Code
InChI=1S/C16H19NO3/c1-12(2)10-17-16(18)6-4-3-5-13-7-8-14-15(9-13)20-11-19-14/h3-9,12H,10-11H2,1-2H3,(H,17,18)/b5-3+,6-4+
InChi Key
WHAAPCGHVWVUEX-GGWOSOGESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $53

    Add

    10 mg

    $69

    Add

    25 mg

    $129

    Add

    50 mg

    $231

    Add
    Product Description

    Piperlonguminine is an alkaloid amide from species of the genus Piper, a plant used in traditional medicine that demonstrates antifungal, anticancer, antihyperlipidemic, and anti-inflammatory properties.1,2 Piperlonguminine (3-12.5 μM) has been shown to dose dependently decrease expression of amyloid precursor protein and amyloid-β peptide in human neuroblastoma cells, suggesting it may have implication in treating Alzheimer’s disease.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kumar, S., Kamboj, J., Suman, et al. Overview for various aspects of the health benefits of Piper longum Linn. fruit. J. Acupunct. Meridian Stud. 4(2), 134-140 (2011).

    2. Silva, D.R., Baroni, S., Svidzinski, A.E., et al. Anti-inflammatory activity of the extract, fractions and amides from the leaves of Piper ovatum Vahl (Piperaceae). J. Ethnopharmacol. 116(3), 569-573 (2008).

    3. Qi, H.S., Liu, P., Gao, S.Q., et al. Inhibitory effect of piperlonguminine/dihydropiperlonguminine on the production of amyloid β and APP in SK-N-SH cells. Chin. J. Physiol. 52(3), 160-168 (2009).