A uPA inhibitor
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UK 122 (trifluoroacetate salt)

Item No. 9001218

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(E)-(5-oxo-2-phenyl-4(5H)-oxazolylidene)methyl]-benzenecarboximidamide, 2,2,2-trifluoroacetate
CAS Number
1186653-73-5
Molecular Formula
C17H13N3O2 • CF3COOH
Formula Weight
405.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: SolubleMethanol: Soluble
SMILES
NC(C1=CC=C(/C=C2N=C(C3=CC=CC=C3)OC/2=O)C=C1)=N.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C17H13N3O2.C2HF3O2/c18-15(19)12-8-6-11(7-9-12)10-14-17(21)22-16(20-14)13-4-2-1-3-5-13;3-2(4,5)1(6)7/h1-10H,(H3,18,19);(H,6,7)/b14-10+;
InChi Key
KVCIDYPYQWLDKP-KMZJGFRYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    Cayman Chemical
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    Product Description

    UK 122 is an inhibitor of urokinase-type plasminogen activator (uPA; IC50 = 0.2 µM).1 It is selective for uPA over tissue-type plasminogen activator (tPA), trypsin, plasmin, and thrombin (IC50s = >100 µM for all). UK 122 (100 µM) inhibits the migration and invasion of CFPAC-1 pancreatic cancer cells. It prevents glutamate-induced phase shifts in isolated suprachiasmatic nucleus slices from tPA-/- but not wild-type mice when used at a concentration of 0.2 µM.2 UK 122 (4 mg/kg) decreases disease severity and colorectal levels of RANTES in a mouse model of colitis induced by dextran sulfate (DSS; Item No. 23250).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhu, M., Gokhale, V.M., Szabo, L., et al. Identification of a novel inhibitor of urokinase-type plasminogen activator. Mol. Cancer Ther. 6(4), 1348-1356 (2007).

    2. Cooper, J.M., Rastogi, A., Krizo, J.A., et al. Urokinase-type plasminogen activator modulates mammalian circadian clock phase regulation in tissue-type plasminogen activator knockout mice. Eur. J. Neurosci. 45(6), 805-815 (2017).

    3. Kida, Y., Okahisa, T., Sato, Y., et al. Urokinase-type plasminogen activator blockade ameliorates experimental colitis in mice. Sci. Rep. 13(1), 2899 (2023).