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BD 1008 (hydrobromide)

Item No. 9001336

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-1-pyrrolidineethanamine, dihydrobromide
CAS Number
138356-09-9
Molecular Formula
C15H22Cl2N2 • 2HBr
Formula Weight
463.1
Purity
≥99%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Water: 50mM
SMILES
ClC1=C(Cl)C=CC(CCN(C)CCN2CCCC2)=C1.Br.Br
InChi Code
InChI=1S/C15H22Cl2N2.2BrH/c1-18(10-11-19-7-2-3-8-19)9-6-13-4-5-14(16)15(17)12-13;;/h4-5,12H,2-3,6-11H2,1H3;2*1H
InChi Key
YTBUMHOSKIAYCZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    BD 1008 (hydrobromide) (Item No. 9001336) is an analytical reference standard that is functionally categorized as a receptor antagonist. It is a selective antagonist of the sigma 1 (σ1) receptor (Ki = 2 nM) that displays 4-fold selectivity for σ1 over σ2.1 BD 1008 is used to modulate signaling through σ receptors by cocaine and in models of learning and memory impairment.2,3,4 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. de Costa, B.R., He, X.S., Dominguez, C., et al. A new approach to the design of sigma-2-selective ligands: synthesis and evaluation of N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-2-(1- pyrrolidinyl)ethylamine-related polyamines at sigma-1 and sigma-2 receptor subtypes. J. Med. Chem. 37(2), 314-321 (1994).

    2. Desai, R.I., Grandy, D.K., Lupica, C.R., et al. Pharmacological characterization of a dopamine transporter ligand that functions as a cocaine antagonist. J. Pharmacol. Exp. Ther. 348(1), 106-115 (2014).

    3. Hiranita, T., Soto, P.L., Kohut, S.J., et al. Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors. J. Pharm. Exp. Ther. 339(2), 662-677 (2011).

    4. Maurice, T., Phan, V.-L., Noda, Y., et al. The attenuation of learning impairments induced after exposure to CO or trimethyltin in mice by sigma (sσ) receptor ligands involves both σ1 and σ2 sites. Br. J. Pharmacol. 127(2), 335-342 (1999).