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Parent Compound(s)
11928UR-144 Degradant
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UR-144 Degradant N-pentanoic acid metabolite

Item No. 9001453

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(3,3,4-trimethyl-1-oxo-4-penten-1-yl)-1H-indole-1-pentanoic acid
CAS Number
1630022-97-7
Molecular Formula
C21H27NO3
Formula Weight
341.5
Purity
≥95%
Formulation
A 10 mg/ml solution in methanol
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlEthanol: 12.5 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
λmax
212, 246, 304 nm
SMILES
O=C(CC(C)(C)C(C)=C)C1=CN(CCCCC(O)=O)C2=C1C=CC=C2
InChi Code
InChI=1S/C21H27NO3/c1-15(2)21(3,4)13-19(23)17-14-22(12-8-7-11-20(24)25)18-10-6-5-9-16(17)18/h5-6,9-10,14H,1,7-8,11-13H2,2-4H3,(H,24,25)
InChi Key
HPKJJMLBDDTMFT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    UR-144 (Item No. 11502) is a potent synthetic cannabinoid (CB) that preferentially binds the peripheral CB2 receptor (Ki = 1.8 nM) over the central CB1 receptor (Ki = 150 nM).1 UR-144 Degradant N-pentanoic acid metabolite (Item No. 9001453) is a potential phase I metabolite of a degradation product observed during GC-MS analysis of samples containing UR-144.2,3,4 The biological activities of this compound have not been characterized. This product is intended for forensic and research applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Frost, J.M., Dart, M.J., Tietje, K.R., et al. Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB2 cannabinoid receptor activity. J. Med. Chem. 53(1), 295-315 (2010).

    2. Wintermeyer, A., Möller, I., Thevis, M., et al. In vitro phase I metabolism of the synthetic cannabimimetic JWH-018. Anal. Bioanal. Chem. 398(5), 2141-2153 (2010).

    3. Chimalakonda, K.C., Moran, C.L., Kennedy, P.D., et al. Solid-phase extraction and quantitative measurement of omega and omega-1 metabolites of JWH-018 and JWH-073 in human urine. Anal. Chem. 83(16), 6381-6388 (2011).

    4. Lovett, D.P., Yanes, E.G., Herbelin, T.W., et al. Structure elucidation and identification of a common metabolite for naphthoylindole-based synthetic cannabinoids using LC-TOF and comparison to a synthetic reference standard. Forensic Sci. Int. 226(1-3), 81-87 (2013).

    Product Citations

    Zhang, L.J., Salekeen, R., Soto-Palma, C., et al. Article polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells. Cell Press Blue 1(1), 100004 (2026).

    Cho, B., Cho, H.S., Kim, J., et al. Simultaneous determination of synthetic cannabinoids and their metabolites in human hair using LC-MS/MS and application to human hair. Forensic Sci. Int. 306, 110058 (2020).