An ester prodrug form of PGE1
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Prostaglandin E1 isopropyl ester

Item No. 9001729

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(11α,13E,15S)-11,15-dihydroxy-9-oxo-prost-13-en-1-oic acid, 1-methylethyl ester
CAS Number
217182-28-0
Synonyms
  • PGE1 isopropyl ester
Molecular Formula
C23H40O5
Formula Weight
396.6
Purity
≥95%
Formulation (Request formulation change)
A 5 mg/ml solution methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 75 mg/mlDMSO: 2 mg/mlEthanol: 100 mg/mlPBS (pH 7.2): 50 mg/ml
SMILES
O=C1[C@H](CCCCCCC(OC(C)C)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1
InChi Code
InChI=1S/C23H40O5/c1-4-5-8-11-18(24)14-15-20-19(21(25)16-22(20)26)12-9-6-7-10-13-23(27)28-17(2)3/h14-15,17-20,22,24,26H,4-13,16H2,1-3H3/b15-14+/t18-,19+,20+,22+/m0/s1
InChi Key
IVJLDARWZNUIAU-WUDJJVMMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

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    Product Description

    Prostaglandin E1 isopropyl ester is an ester prodrug form of prostaglandin E1 (PGE1; Item No. 13010) with enhanced lipid solubility.1,2 The ester functional group on PGE1 isopropyl ester is readily hydrolyzed in cells and in vivo to release active PGE1.1 PGE1 isopropyl ester exhibits a faster penetration flux than the free acid form of PGE1 when applied topically to isolated mouse skin. Topical administration of PGE1 isopropyl ester (1 mM) reduces fluid pressure within human dermal fibroblast cell aggregates.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ho, H.O., Hwang, M.C., Tseng, S.L., et al. The percutaneous penetration of prostaglandin E1 and its alkyl esters. J. Control Release 58(3), 349-355 (1999).

    2. Stuhr, L.E., Reith, A., Lepsøe, S., et al. Fluid pressure in human dermal fibroblast aggregates measured with micropipettes. Am. J. Physiol. Cell Physiol. 285(5), C1101-1108 (2003).