An esterified form of PGE1
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Prostaglandin E1 ethyl ester

Item No. 9001730

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11α,15S-dihydroxy-9-oxo-prost-13E-en-1-oic acid, ethyl ester
CAS Number
35900-16-4
Synonyms
  • Alprostadil ethyl ester
  • PGE1 ethyl ester
Molecular Formula
C22H38O5
Formula Weight
382.5
Purity
≥95%
Formulation (Request formulation change)
A 1 mg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 0.25 mg/ml
λmax
288 nm
SMILES
O=C1[C@H](CCCCCCC(OCC)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1
InChi Code
InChI=1S/C22H38O5/c1-3-5-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-7-10-13-22(26)27-4-2/h14-15,17-19,21,23,25H,3-13,16H2,1-2H3/b15-14+/t17-,18+,19+,21+/m0/s1
InChi Key
LVDCZROIKIHUKJ-QZCLESEGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

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    Product Description

    Prostaglandin E1 (PGE1) is the theoretical cyclooxygenase metabolite of dihomo-γ-linolenic acid.1 Its pharmacology includes vasodilation, hypotension, and anti-platelet activities. The IC50 value of PGE1 for the inhibition of ADP-induced human platelet aggregation is 40 nM.2,3 PGE1 is used to treat male erectile dysfunction and to maintain ductus arteriosus patency in infants.4,5 PGE1 ethyl ester is an esterified form of the free acid which may be more amenable for certain applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cawello, W., Schweer, H., Dietrich, B., et al. Pharmacokinetics of prostaglandin E1 and its main metabolites after intracavernous injection and short-term infusion of prostaglandin E1 in patients with erectile dysfunction. J. Urol. 158(4), 1403-1407 (1997).

    2. Kobzar, G., Mardla, V., Järving, I., et al. Antiaggregating potency of E-type prostaglandins in human and rabbit platelets. Proc. Estonian Acad. Sci. Chem. 40(N3), 179-180 (1991).

    3. Okada, F., Nukada, T., Yamauchi, Y., et al. The hypotensive effect of prostaglandin E1 on hypertensive cases of various types. Prostaglandins 7(2), 99-106 (1974).

    4. Padma-Nathan, H., Hellstrom, W.J.G., Kaiser, F.E., et al. Treatment of men with erectile dysfunction with transurethral alprostadil. N. Engl. J. Med. 336(1), 1-7 (1997).

    5. Olley, P.M., and Coceani, F. Prostaglandins and the ductus arteriosus. Annu. Rev. Med. 32, 375-3785 (1981).