An intermediate in the citric acid cycle
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α-Ketoglutaric Acid (sodium salt)

Item No. 9001828

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-oxo-pentanedioic acid, monosodium salt
CAS Number
22202-68-2
Synonyms
  • α-KGA
  • 2-Oxoglutaric Acid
Molecular Formula
C5H6O5 • Na
Formula Weight
169.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C(C(CCC(O)=O)=O)O.[Na]
InChi Code
InChI=1S/C5H6O5.Na/c6-3(5(9)10)1-2-4(7)8;/h1-2H2,(H,7,8)(H,9,10);
InChi Key
GPRYXSKURSLOCH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 g

    $41

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    5 g

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    Product Description

    α-Ketoglutaric acid is an α-keto acid and a rate-determining metabolic intermediate in the citric acid cycle in its conjugate base form, α-ketoglutarate.1,2 It is formed via oxidative decarboxylation of isocitrate by isocitrate dehydrogenase (IDH), oxidative deamination of glutamate by glutamate dehydrogenase, or by pyridoxal phosphate-dependent transamination.2 α-Ketoglutaric acid is decarboxylated to succinyl-CoA by α-ketoglutarate dehydrogenase, a rate limiting step in the citric acid cycle. It is a precursor of glutamine and glutamate, energy sources for enterocytes and various immune cells, and an antioxidant with roles in immune homeostasis, aging, protein synthesis, and bone development.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Krebs, H.A., Salvin, E., and Johnson, W.A. The formation of citric and α-ketoglutaric acids in the mammalian body. Biochem. J. 32(1), 113-117 (1938).

    2. Wu, N., Yang, M., Gaur, U., et al. Alpha-ketoglutarate: Physiological functions and applications. Biomol. Ther. (Seoul) 24(1), 1-8 (2016).

    3. Liu, S., He, L., and Yao, K. The antioxidative function of alpha-ketoglutarate and its applications. Biomed. Res. Int. 3408467 (2018).