An inhibitor of mPGES-1
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AF3485

Item No. 9001962

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[9-(2-hydroxyethyl)-9H-carbazol-3-yl]-2-(trifluoromethyl)-benzamide
CAS Number
1195786-61-8
Synonyms
  • CAY10686
Molecular Formula
C22H17F3N2O2
Formula Weight
398.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2); (1:7): 0.1 mg/mlDMSO: 10 mg/mlEthanol: 0.3 mg/ml
λmax
240, 281, 350 nm
SMILES
OCCN(C1=C2C=CC=C1)C3=C2C=C(NC(C4=CC=CC=C4C(F)(F)F)=O)C=C3
InChi Code
InChI=1S/C22H17F3N2O2/c23-22(24,25)18-7-3-1-6-16(18)21(29)26-14-9-10-20-17(13-14)15-5-2-4-8-19(15)27(20)11-12-28/h1-10,13,28H,11-12H2,(H,26,29)
InChi Key
RXVOFPXZHVKZIL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $75

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    5 mg

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    10 mg

    $516

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    Product Description

    AF3485 is a selective 3-aminocarbazole inhibitor of mPGES-1, blocking the synthesis of PGE2 but not PGF2α (Item No. 16010) in A549 cells stimulated with IL-1β (IC50s = 2.9 and >100 µM, respectively).1 It reduces inflammatory pain (acetic acid-induced writhing) in mice by 74% when given intraperitoneally at 10 mg/kg.1 AF3485 is absorbed through enterocytes, is metabolically stable in human and rat microsome preparations, and is bioavailable in vivo.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alisi, M.A., Cazzolla, N., Coletta, I., et al. 3-Aminocarbazole compound, pharmaceutical composition containing it and preparation method therefor. PCT/EP2009/055652, 1-38 (2009).