An analog of arachidonic acid with acetylene in the 5,6 position
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5,6-dehydro Arachidonic Acid

Item No. 90020

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8Z,11Z,14Z-eicosatrien-5-ynoic acid
CAS Number
58688-54-3
Synonyms
  • 5,6-dehydro AA
  • FA 20:5
Molecular Formula
C20H30O2
Formula Weight
302.5
Purity
≥98%
Formulation
A 100 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
0.15 M Tris-HCl pH 8.5: >1 mg/ml (from Oleic Acid)DMF: >100 mg/ml (from Oleic Acid)DMSO: >100 mg/ml (from Oleic Acid)Ethanol: >100 mg/ml (from Oleic Acid)PBS pH 7.2: <100 µg/ml (from Oleic Acid)
SMILES
CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(=O)O
InChi Code
InChI=1S/C20H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h6-7,9-10,12-13H,2-5,8,11,14,17-19H2,1H3,(H,21,22)/b7-6-,10-9-,13-12-
InChi Key
GIOQWSLKUVKKAO-QNEBEIHSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    25 µg

    $108

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    50 µg

    $205

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    100 µg

    $387

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    Product Description

    5,6-dehydro Arachidonic acid is an analog of arachidonic acid with an acetylene in the 5,6 position. It inhibits 5-LO in rat basophilic leukemia cells, with a Ki value of 15 µM.1 In guinea pig leukocytes, 5-LO is inhibited by 5,6-dehydro arachidonic acid with an IC50 value of 10 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kohyama, N., Nagata, T., Fujimoto, S., et al. Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives. Biosci. Biotechnol. Biochem. 61(2), 347-350 (1997).

    2. Sok, D.E., Han, C.Q., Pai, J.K., et al. Inhibition of leukotriene biosynthesis by acetylenic analogs. Biochem. Biophys. Res. Commun. 107, 101-108 (1982).