A selective BCATc inhibitor
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BCATc Inhibitor 2

Item No. 9002002

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-chloro-2-benzofurancarboxylic acid 2-[[2-(trifluoromethyl)phenyl]sulfonyl]hydrazide
CAS Number
406191-34-2
Synonyms
  • Cytosolic Branched-Chain Amino Acid Transferase Inhibitor 2
Molecular Formula
C16H10ClF3N2O4S
Formula Weight
418.8
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/ml
λmax
215, 275 nm
SMILES
ClC1=CC=C2C(C=C(C(NNS(C3=C(C(F)(F)F)C=CC=C3)(=O)=O)=O)O2)=C1
InChi Code
InChI=1S/C16H10ClF3N2O4S/c17-10-5-6-12-9(7-10)8-13(26-12)15(23)21-22-27(24,25)14-4-2-1-3-11(14)16(18,19)20/h1-8,22H,(H,21,23)
InChi Key
ZLQBZYKAQQWOTK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $213

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    10 mg

    $376

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    50 mg

    $1,286

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    Product Description

    BCATc inhibitor 2 is a sulfonyl hydrazide that inhibits BCATc (IC50s = 0.81 and 0.2 µM for human and rat, respectively) with 15-fold selectivity over BCATm.1,2,3 This compound has been shown to block calcium influx into neurons (IC50 = 4.8 µM) following inhibition of glutamate uptake and to demonstrate neuroprotective efficacy in an in vivo rat model of neurodegeneration.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bora, K., Hu, L.Y., Kesten, S.R., et al. Branched chain amino acid-dependent aminotransferase inhibitors and their use in the treatment of neurodegenerative diseases. PCT/US01/25892, (2002).

    2. Hu, L.Y., Boxer, P.A., Kesten, S.R., et al. The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases. Bioorg. Med. Chem. Lett. 16(9), 2337-2340 (2006).

    3. Caballero, J., Vergara-Jaque, A., Fernández, M., et al. Docking and quantitative structure-activity relationship studies for sulfonyl hydrazides as inhibitors of cytosolic human branched-chain amino acid aminotransferase. Mol. Divers. 13(4), 493-500 (2009).