A cephalosporin antibiotic that inactivates PBP3
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Cephalexin

Item No. 9002009

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS Number
15686-71-2
Synonyms
  • Cefalexin
Molecular Formula
C16H17N3O4S
Formula Weight
347.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
1 M NH4OH: 25 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
205, 265 nm
SMILES
O=C(N[C@@H]1C(N2[C@]1([H])SCC(C)=C2C(O)=O)=O)[C@H](N)C3=CC=CC=C3
InChi Code
InChI=1S/C16H17N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-6,10-11,15H,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1
InChi Key
ZAIPMKNFIOOWCQ-UEKVPHQBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 g

    $36

    Add

    5 g

    $70

    Add

    10 g

    $120

    Add

    25 g

    $229

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Cephalexin is a cephalosporin antibiotic that is active against most Gram-positive cocci, including penicillinase-producing Staphylococci, and against Gram-negative bacteria such as N. gonorrhoeae, E. coli, K. pneumonia, Salmonellae, Shigella, and some strains of H. influenza.1 It is not effective against Proteus species, Pseudomonas, or mycobacteria.1 Cephalexin specifically inactivates penicillin-binding protein (PBP) 3, which is essential for bacterial cell wall synthesis.2 It has been combined with antibiotics that preferentially target alternate PBP isotypes as a strategy to combat drug-resistant bacteria.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bailey, A., Walker, A., Hadley, A., et al. Cephalexin. A new oral antibiotic. Torax. 20(1), 15-19 (1971).

    2. Iwai, N., Nagai, K., and Wachi, M. Novel S-benzylisothiourea compound that induces spherical cells in Escherichia coli probably by acting on a rod-shape-determining protein(s) other than penicillin-binding protein 2. Biosci. Biotechnol. Biochem. 66(12), 2658-2662 (2002).

    3. Sarkar, S.K., Dutta, M., Kumar, A., et al. Sub-inhibitory cefsulodin sensitization of E. coli to ß-lactams is mediated by PBP1b inhibition. PLoS One 7(11), (2012).