A sensitive substrate for proteinase 3
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Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp (trifluoroacetate salt)

Item No. 9002021

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(2-aminobenzoyl)-L-valyl-L-alanyl-L-α-aspartyl-L-norvalyl-L-arginyl-L-α-aspartyl-L-arginyl-N1-[2-[(2,4-dinitrophenyl)amino]ethyl]-L-glutamamide, trifluoroacetate salt
Molecular Formula
C53H80N20O18 • XCF3COOH
Formula Weight
1285.3
Purity
≥98%
Formulation (Request formulation change)
A lyophilized powder
Solubility(Learn about Variance in Solubility)
DMSO: SolubleWater: Soluble
λmax
252, 345 nm
SMILES
O=C(NCCNC1=CC=C([N+]([O-])=O)C=C1[N+]([O-])=O)[C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCC)NC([C@@H](NC([C@@H](NC([C@@H](NC(C2=CC=CC=C2N)=O)C(C)C)=O)C)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)CC(O)=O)=O)CCCNC(N)=N)=O)CCC(N)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C53H80N20O18.C2HF3O2/c1-5-10-32(65-49(85)36(24-40(75)76)69-43(79)27(4)64-51(87)42(26(2)3)71-44(80)29-11-6-7-12-30(29)54)46(82)66-34(14-9-20-63-53(58)59)48(84)70-37(25-41(77)78)50(86)67-33(13-8-19-62-52(56)57)47(83)68-35(17-18-39(55)74)45(81)61-22-21-60-31-16-15-28(72(88)89)23-38(31)73(90)91;3-2(4,5)1(6)7/h6-7,11-12,15-16,23,26-27,32-37,42,60H,5,8-10,13-14,17-22,24-25,54H2,1-4H3,(H2,55,74)(H,61,81)(H,64,87)(H,65,85)(H,66,82)(H,67,86)(H,68,83)(H,69,79)(H,70,84)(H,71,80)(H,75,76)(H,77,78)(H4,56,57,62)(H4,58,59,63);(H,6,7)/t27-,32-,33-,34-,35-,36-,37-,42-;/m0./s1
InChi Key
MEGBHGOPLUPBRV-NBEUBOQESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $303

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    Product Description

    Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1).1 Enzymatic peptide hydrolysis disrupts the Abz:EDDnp donor-acceptor pair allowing fluorescence measurement of Abz (ex = 320 nm; em = 420 nm).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Korkmaz, B., Attucci, S., Juliano, M.A., et al. Measuring elastase, proteinase 3 and cathepsin G activities at the surface of human neutrophils with fluorescence resonance energy transfer substrates. Nat. Protoc. 3(6), 991-1000 (2008).

    Product Citations

    Xiao, Y., Cong, M., Li, J., et al. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Cancer Cell 39(3), 423-437 (2021).