An affinity probe for TXB2 binding partners
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Unmodified Version(s)
19030Thromboxane B2
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Thromboxane B2-biotin

Item No. 9002298

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(Z)-7-((2R,3S,4S)-4,6-dihydroxy-2-((S,E)-3-hydroxyoct-1-en-1-yl)tetrahydro-2H-pyran-3-yl)-N-(5-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)pentyl)hept-5-enamide
Synonyms
  • TXB2-biotin
Molecular Formula
C35H60N4O7S
Formula Weight
681.0
Purity
≥90%
Formulation (Request formulation change)
A 500 µg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: 5 mg/ml
SMILES
O[C@@H]1[C@H](C/C=C\CCCC(NCCCCCNC(CCCC[C@H]2[C@]3([H])[C@](NC(N3)=O)([H])CS2)=O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)OC(O)C1
InChi Code
InChI=1S/C35H60N4O7S/c1-2-3-7-14-25(40)19-20-29-26(28(41)23-33(44)46-29)15-8-4-5-9-17-31(42)36-21-12-6-13-22-37-32(43)18-11-10-16-30-34-27(24-47-30)38-35(45)39-34/h4,8,19-20,25-30,33-34,40-41,44H,2-3,5-7,9-18,21-24H2,1H3,(H,36,42)(H,37,43)(H2,38,39,4
InChi Key
HUDAMYXUDLGXNK-BUZULNEHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 µg

    $90

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    100 µg

    $168

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    500 µg

    $567

    Add

    1 mg

    $1,042

    Add
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    Product Description

    Thromboxane A2 (TXA2) is produced from arachidonic acid (Item No. 90010) by many cells and causes irreversible platelet aggregation and contraction of vascular and bronchial smooth muscle.1,2,3 TXA2 is rapidly hydrolyzed non-enzymatically to TXB2 (Item No. 19030), which is then quickly metabolized to urinary metabolites for clearance by the kidneys. TXB2-biotin is an affinity probe which allows TXB2 to be detected through an interaction with the biotin ligand. It was designed to allow TXB2 to be detected in complexes with protein binding partners.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hamberg, M., Svensson, J., and Samuelsson, B. Thromboxanes: A new group of biologically active compounds derived from prostaglandin endoperoxides. Proc. Natl. Acad. Sci. USA 72(8), 2994-2998 (1975).

    2. Ellis, E.F., Oelz, O., Roberts, L.J., II, et al. Coronary arterial smooth muscle contraction by a substance released from platelets: Evidence that it is thromboxane A2. Science 193(4258), 1135-1137 (1976).

    3. Salzman, P.M., Salmon, J.A., and Moncada, S. Prostacyclin and thromboxane A2 synthesis by rabbit pulmonary artery. J. Pharmacol. Exp. Ther. 215(1), 240-247 (1980).