A non-nucleoside reverse transcriptase inhibitor
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MIV-150

Item No. 9002360

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(5-cyano-2-pyridinyl)-N-[(1S,2S)-2-[6-fluoro-2-hydroxy-3-(1-oxopropyl)phenyl]cyclopropyl]-urea
CAS Number
231957-54-3
Synonyms
  • PC-815
Molecular Formula
C19H17FN4O3
Formula Weight
368.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 0.25 mg/ml
λmax
210, 262 nm
SMILES
FC1=C([C@H]2[C@@H](NC(NC3=NC=C(C#N)C=C3)=O)C2)C(O)=C(C(CC)=O)C=C1
InChi Code
InChI=1S/C19H17FN4O3/c1-2-15(25)11-4-5-13(20)17(18(11)26)12-7-14(12)23-19(27)24-16-6-3-10(8-21)9-22-16/h3-6,9,12,14,26H,2,7H2,1H3,(H2,22,23,24,27)/t12-,14+/m1/s1
InChi Key
NKPHEWJJTGPRSL-OCCSQVGLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $121

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    1 mg

    $215

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    5 mg

    $833

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    10 mg

    $1,190

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    Product Description

    MIV-150 is a tight-binding, allosteric inhibitor of reverse transcriptase that is active against HIV-1 and HIV-2 (both EC50s = 1 nM in vitro).1 It has been shown to inactivate viruses that are resistant to other antiviral drugs, including non-nucleoside reverse transcriptase inhibitors, nucleoside reverse transcriptase inhibitors, and protease inhibitors.1 Although MIV-150 possesses poor oral bioavailability, it demonstrates efficacy when formulated as a topical microbicide.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fernández-Romero, J.A., Thorn, M., Turville, S.G., et al. Carrageenan/MIV-150 (PC-815), a combination microbicide. Sex. Transm. Dis. 34(1), 9-14 (2007).

    2. Turville, S.G., Aravantinou, M., Miller, T., et al. Efficacy of Carraguardr-based microbicides in vivo despite variable in vitro activity. PLoS One 3(9), e3162 (2008).

    3. Singer, R., Derby, N., Rodriguez, A., et al. The nonnucleoside reverse transcriptase inhibitor MIV-150 in carrageenan gel prevents rectal transmission of simian/human immunodeficiency virus infection in macaques. J. Virol. 85(11), 5504-5512 (2011).