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Propofol Sulfate (sodium salt)

Item No. 9002416

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(hydrogen sulfate) 2,6-bis(1-methylethyl)-phenol, monosodium salt
Molecular Formula
C12H17O4S • Na
Formula Weight
280.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CC(C)C1=CC=CC(C(C)C)=C1OS([O-])(=O)=O.[Na+]
InChi Code
InChI=1S/C12H18O4S.Na/c1-8(2)10-6-5-7-11(9(3)4)12(10)16-17(13,14)15;/h5-9H,1-4H3,(H,13,14,15);/q;+1/p-1
InChi Key
HWROCHTUCLVXNZ-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $69

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    5 mg

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    10 mg

    $525

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    Product Description

    Propofol is a short-acting anesthetic agent that acts as a potentiator of the GABAA receptor (EC50 = 10 µM).1,2,3,4 It also has direct activation effects at the GABAA receptor, alters receptor desensitization and deactivation, and blocks channel activity.2 Propofol shows little or no specificity among the diverse GABAA receptor subunits.2 Intravenous injection of propofol is usually accompanied with pain due to activation of the transient receptor potential ankyrin 1 channel.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sooksawate, T., and Simmonds, M.A. Influence of membrane cholesterol on modulation of the GABAA receptor by neuroactive steroids and other potentiators. Br. J. Pharmacol. 134, 1303-1311 (2001).

    2. Krasowski, M.D., Hong, X., Hopfinger, A.J., et al. 4D-QSAR analysis of a set of propofol analogues: mapping binding sites for an anesthetic phenol on the GABAA receptor. J. Med. Chem. 45(15), 3210-3221 (2002).

    3. Lingamaneni, R., and Hemmings, H.C., Jr. Differential interaction of anaesthetics and antiepileptic drugs with neuronal Na+ channels, Ca2+ channels, and GABAA receptors. Br. J. Anaesth. 90(2), 199-211 (2003).

    4. Li, M., Zhao, X., Zhang, L., et al. Effects and safety of magnesium sulfate on propofol-induced injection pain, a meta-analysis of randomized controlled trials. Int. J. Clin. Exp. Med. 8(5), 6813-6821 (2015).

    5. Baraldi, P.G., Preti, D., Materazzi, S., et al. Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J. Med. Chem. 53(14), 5085-5107 (2010).