A neurotransmitter/fatty acid conjugate
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Labeled Version(s)
19104Prostaglandin D2 Dopamine-d4
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Prostaglandin D2 Dopamine

Item No. 9002504

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9α,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic N-[2-(3,4-dihydroxyphenyl)ethyl amide
Synonyms
  • PGD2 DA
  • PGD2 Dopamine
Molecular Formula
C28H41NO6
Formula Weight
487.6
Purity
≥95%
Formulation (Request formulation change)
A 1 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 50 mg/mlEthanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
O[C@@H](C1)[C@H](C/C=C\CCCC(NCCC2=CC=C(O)C(O)=C2)=O)[C@@H](/C=C/[C@@H](O)CCCCC)C1=O
InChi Code
InChI=1S/C28H41NO6/c1-2-3-6-9-21(30)13-14-23-22(25(32)19-26(23)33)10-7-4-5-8-11-28(35)29-17-16-20-12-15-24(31)27(34)18-20/h4,7,12-15,18,21-23,25,30-32,34H,2-3,5-6,8-11,16-17,19H2,1H3,(H,29,35)/b7-4-,14-13+/t21-,22+,23+,25-/m0/s1
InChi Key
LAUDQVBGQWVXEM-KCTPEUGASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $117

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    1 mg

    $218

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    5 mg

    $909

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    Product Description

    Prostaglandin D2 (PGD2; Item No. 12010), the major eicosanoid product of mast cells in the immune system, is also produced in the brain where it is involved in sleep regulatory mechanisms.1,2 Further pharmacological actions include inhibition of platelet aggregation, relaxation of vascular smooth muscle, and regulation of reproductive development.3 Dopamine-containing neurons in the brain are involved in reward-motivated behavior, motor control, and hormone release.4 Peripheral, paracrine actions of dopamine include the control of vasodilation, sodium excretion, insulin production, gastrointestinal motility, and the activity of lymphocytes.2,5 Catecholamines are known to stimulate prostanoid synthesis by acting as co-substrates.6 PGD2 dopamine is a conjugate of the neurotransmitter dopmaine and PGD2. It can be used to study the biological function of PGD2 in the brain and periphery.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roberts, L.J., II, and Sweetman, B.J. Metabolic fate of endogenously synthesized prostaglandin D2 in a human female with mastocytosis. Prostaglandins 30(3), 383-400 (1985).

    2. Hayaishi, O. Molecular genetic studies on sleep-wake regulation, with special emphases on the prostaglandin D2 system. J. Appl. Physiol. 92(2), 863-868 (2015).

    3. Giles, H., and Leff, P. The biology and pharmacology of PGD2. Prostaglandins 35(2), 277-300 (1988).

    4. Missale, C., Nash, S.R., Robinson, S.W., et al. Dopamine receptors: From structure to function. Physiol. Rev. 78(1), 190-225 (1998).

    5. Garza, J.H.H., and Carr, D.J.J. Neuroendocrine peptide receptors on cells of the immune system. Chem. Immunol. 69, 132-154 (1997).

    6. Alanko, J., Riutta, A., and Vapaatalo, H. Effects of catecholamines on eicosanoid synthesis with special reference to prostanoid/leukotriene ratio. Free Radic. Biol. Med. 13(6), 677-688 (1992).