An internal standard for the quantification of 11-keto Testosterone
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Unlabeled Version(s)
900256411-keto Testosterone (CRM)
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11-keto Testosterone-d3

Item No. 9002754

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(17β)-17-hydroxy-androst-4-ene-3,11-dione-16,16,17-d3
CAS Number
2479914-03-7
Molecular Formula
C19H23D3O3
Formula Weight
305.4
Purity
≥99% deuterated forms (d1-d3)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:10): 0.09 mg/mlEthanol: 20 mg/ml
λmax
237 nm
SMILES
O[C@@]1([2H])C([2H])([2H])C[C@@]([C@]1(C)C2)([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])C2=O)=O
InChi Code
InChI=1S/C19H26O3/c1-18-8-7-12(20)9-11(18)3-4-13-14-5-6-16(22)19(14,2)10-15(21)17(13)18/h9,13-14,16-17,22H,3-8,10H2,1-2H3/t13-,14-,16-,17+,18-,19-/m0/s1/i6D2,16D
InChi Key
WTPMRQZHJLJSBO-GFWWJJFOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $169

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    Product Description

    11-keto Testosterone-d3 (Item No. 9002754) is intended for use as an internal standard for the quantification of 11-keto testosterone (CRM) (Item No. 9002564) by GC- or LC-MS. 11-keto Testosterone is structurally categorized as an androgen. It is a significant hormone in certain fish, regulating the development of sexual development and behavior.1,2 11-keto Testosterone binds the stickleback kidney androgen receptor (EC50 = 43 nM).3 11-keto Testosterone, at 10 nM, significantly activates the human androgen receptor expressed in zebrafish liver cells.3 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamaguchi, T., Watanuki, H., and Sakai, M. Effects of estradiol, progesterone and testosterone on the function of carp, Cyprinus Carpio, phagocytes in vitro. Comp. Biochem. Physiol. 129C(1), 49-55 (2001).

    2. Godwin, J. Neuroendocrinology of sexual plasticity in teleost fishes. Front.Neuroendocrinol. 31(2), 203-216 (2010).

    3. Olsson, P.E., Berg, A.H., von Hofsten, J., et al. Molecular cloning and characterization of a nuclear androgen receptor activated by 11-ketotestosterone. Reprod. Biol. Endocrinol. 3:37, (2005).

    Product Citations

    van Rooyen, D., Yadav, R., Scott, E.E., et al. CYP17A1 exhibits 17αhydroxylase/17,20-lyase activity towards 11β-hydroxyprogesterone and 11-ketoprogesterone metabolites in the C11-oxy backdoor pathway. J. Steroid Biochem. Mol. Biol. 199, 105614 (2020).