A protein cross-linking probe with collision-induced dissociation-cleavable sites
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Product Categories

Product Type

Biochemicals
Labeling & Detection
Reactive Probes

Research Area

Application

Mass Spectrometry

Disuccinimidyl Sulfoxide

Item No. 9002863

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,3'-sulfinylbis-propanoic acid, 1,1'-bis(2,5-dioxo-1-pyrrolidinyl) ester
CAS Number
1351828-03-9
Synonyms
  • DSSO
Molecular Formula
C14H16N2O9S
Formula Weight
388.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2)(1:5): 0.15 mg/ml
SMILES
O=C(CCS(CCC(ON1C(CCC1=O)=O)=O)=O)ON2C(CCC2=O)=O
InChi Code
InChI=1S/C14H16N2O9S/c17-9-1-2-10(18)15(9)24-13(21)5-7-26(23)8-6-14(22)25-16-11(19)3-4-12(16)20/h1-8H2
InChi Key
XJSVVHDQSGMHAJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 mg

    $54

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    100 mg

    $103

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    250 mg

    $229

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    500 mg

    $378

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    Product Description

    Disuccinimidyl sulfoxide (DSSO) is a protein cross-linking probe designed to be used with mass spectrometry (MS). It contains two symmetric collision-induced dissociation (CID)-cleavable sites that allow effective identification of DSSO-cross-linked peptides based on their distinct fragmentation patterns.1 The CID-induced separation of interlinked peptides in MS/MS permits MS3 analysis of single peptide chain fragment ions with defined modifications, due to DSSO remnants, for easy interpretation and unambiguous identification using existing database searching tools.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kao, A., Chiu, C.-l., Vellucci, D., et al. Development of a novel cross-linking strategy for fast and accurate identification of cross-linked peptides of protein complexes. Mol. Cell. Proteomics 10(1), M110.002212 (2011).