A G3BP2 inhibitor

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Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

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Product Type

Research Area

Compound C108

Name: Compound C108
Brand: -

Item No. 9002951

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)

Technical Information

Formal Name

2-hydroxy-benzoic acid, 2-[1-(2-hydroxyphenyl)ethylidene]hydrazide

CAS Number

15533-09-2

Molecular Formula

C₁₅H₁₄N₂O₃

Formula Weight

270.3

Purity

≥98%

Formulation (Request formulation change)

A crystalline solid

Solubility(Learn about Variance in Solubility)

DMF: 1 mg/mlDMF:PBS(pH 7.2)(1:6): 0.14 mg/mlDMSO: 1 mg/ml

λ_max

286, 330 nm

SMILES

OC1=C(/C(C)=N/NC(C2=C(O)C=CC=C2)=O)C=CC=C1

InChi Code

InChI=1S/C15H14N2O3/c1-10(11-6-2-4-8-13(11)18)16-17-15(20)12-7-3-5-9-14(12)19/h2-9,18-19H,1H3,(H,17,20)/b16-10+

InChi Key

LQGMBUGEAAGJKW-MHWRWJLKSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

500 µg

$81

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1 mg

$152

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5 mg

$633

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Product Description

Compound C108 is an inhibitor of the GTPase-activating protein (SH3 domain)-binding protein 2 (G3BP2), which is involved in breast tumor initiation.¹ In a mouse xenograft model of breast cancer, compound C108 (1 µM for 24 hours) reduces the proportion of tumor-initiating cells approximately 10-fold compared with untreated cells. In MDA-MB-453 cells, and in the patient-derived xenograft cell line MAXF 401, it diminishes mammosphere formation.

WARNING This product is not for human or veterinary use.

References & Product Citations

Product Description References

1. Gupta, N., Badeaux, M., Liu, Y., et al. Stress granule-associated protein G3BP2 regulates breast tumor initiation. Proc. Natl. Acad. Sci. USA 114(5), 1033-1038 (2017).

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