A modulator of the CB1 receptor and PPARα
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N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide

Item No. 9002954

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(3,4-dihydroxyphenyl)-1-methylethyl]-9Z-octadecenamide
CAS Number
1258011-97-0
Molecular Formula
C27H45NO3
Formula Weight
431.7
Purity
≥97%
Formulation
A 1 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/mlEthanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
SMILES
O=C(NC(C)CC1=CC=C(O)C(O)=C1)CCCCCCC/C=C\CCCCCCCC
InChi Code
InChI=1S/C27H45NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-27(31)28-23(2)21-24-19-20-25(29)26(30)22-24/h10-11,19-20,22-23,29-30H,3-9,12-18,21H2,1-2H3,(H,28,31)/b11-10-
InChi Key
XIPFMGYXSZQUGV-KHPPLWFESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    100 µg

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    Product Description

    N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide binds to the cannabinoid 1 (CB1) receptor with a Ki value of 365 nM in a radioligand binding assay using rat brain homogenate.1 It has an EC50 value of 698 nM for the peroxisome proliferator-activated receptor α (PPARα) in a luciferase reporter assay and, in rats, it decreases food intake. It does not inhibit fatty acid amide hydrolase (FAAH).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Almeida, B., Joglar, J., Rojas, M.J.L., et al. Synthesis of fatty acid amides of catechol metabolites that exhibit antiobesity properties. ChemMedChem 4;5(10), 1781-1787 (2010).