An intermediate in the biosynthesis of cholesterol
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Lathosterol

Item No. 9003102

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5α-cholest-7-en-3β-ol
CAS Number
80-99-9
Synonyms
  • Δ7-Cholestenol
  • γ-Cholestenol
Molecular Formula
C27H46O
Formula Weight
386.7
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 0.1 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
λmax
210, 272, 282 nm
SMILES
CC(C)CCC[C@@H](C)[C@@]1([H])CC[C@@]2([H])C3=CC[C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h10,18-21,23-25,28H,6-9,11-17H2,1-5H3/t19-,20+,21+,23-,24+,25+,26+,27-/m1/s1
InChi Key
IZVFFXVYBHFIHY-SKCNUYALSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    25 mg

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    50 mg

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    100 mg

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    Product Description

    Lathosterol is an intermediate in the biosynthesis of cholesterol.1,2 Serum levels of lathosterol correlate with cholesterol synthesis and have been used as biomarkers of excess cholesterol production. Lathosterol accumulates in lathosterolosis, a disorder characterized by a deficiency of lathosterol 5-desaturase, the enzyme that converts lathosterol to 7-dehydro cholesterol (Item No. 14612).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kempen, H.J., Glatz, J.F., Gevers Leuven, J.A., et al. Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans. J. Lipid Res. 29(9), 1149-1155 (1988).

    2. Wu, A.H., Ruan, W., Todd, J., et al. Biological variation of β-sitosterol, campesterol, and lathosterol as cholesterol absorption and synthesis biomarkers. Clin. Chim. Acta 430, 43-47 (2014).

    3. Krakowiak, P.A., Wassif, C.A., Kratz, L., et al. Lathosterolosis: An inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase deficiency. Hum. Mol. Genet. 12(13), 1631-1641 (2003).