A partial agonist of the androgen receptor
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YK-11

Item No. 9003137

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(20E)-17α,20-[(1-methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid, methyl ester
CAS Number
1370003-76-1
Molecular Formula
C25H34O6
Formula Weight
430.5
Purity
≥95% (mixture of diastereomers)
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: 1 mg/mlEthanol: 1 mg/mlMethanol: 1 mg/ml
λmax
242 nm
SMILES
O=C(OC)/C=C1OC(OC)(C)O[C@@]2/1CC[C@@]3([H])[C@]4([H])CCC5=CC(CC[C@]5([H])[C@@]4([H])CC[C@@]32C)=O
InChi Code
InChI=1S/C25H34O6/c1-23-11-9-18-17-8-6-16(26)13-15(17)5-7-19(18)20(23)10-12-25(23)21(14-22(27)28-3)30-24(2,29-4)31-25/h13-14,17-20H,5-12H2,1-4H3/b21-14+/t17-,18+,19+,20-,23-,24?,25+/m0/s1
InChi Key
KCQHQCDHFVGNMK-PQUNLUOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    50 mg

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    100 mg

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    Product Description

    YK-11 is an androgen receptor partial agonist that activates androgen receptor transcriptional activity in HEK293 cells overexpressing androgen receptors when used at a concentration of 0.1 μM.1 It induces expression of the androgen receptor target genes FKBP51 and FGF18 in HEK293 cells when used at a concentration of 10 μM. YK-11 accelerates nuclear translocation of androgen receptors without inducing interaction between the androgen receptor N- and C-termini. In C2C12 cells, YK-11 (500 nM) increases expression of the myogenic regulatory factors MyoD, Myf5, and myogenin, as well as follistatin (Fst), and induces myogenic differentiation.2 YK-11 also accelerates proliferation and mineralization and increases expression of the osteoblast differentiation markers osteoprotegerin and osteocalcin in MC3T3-E1 mouse osteoblast cells.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kanno, Y., Hikosaka, R., Zhang, S.-Y., et al. (17α,20E)-17,20-[(1-Methoxyethylidene)bis(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11) is a partial agonist of the androgen receptor. Biol. Pharm. Bull. 34(3), 318-323 (2011).

    2. Kanno, Y., Ota, R., Someya, K., et al. Selective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression. Biol. Pharm. Bull. 36(9), 1460-1465 (2013).

    3. Yatsu, T., Kusakabe, T., Kato, K., et al. Selective androgen receptor modulator, YK11, up-regulates osteoblastic proliferation and differentiation in MC3T3-E1 cells. Biol. Pharm. Bull. 41(3), 394-398 (2018).