A steroid sulfatase inhibitor
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STX-64

Item No. 9003206

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
sulfamic acid, 6,7,8,9,10,11-hexahydro-6-oxobenzo[b]cyclohepta[d]pyran-3-yl ester
CAS Number
288628-05-7
Synonyms
  • BN83495
  • 667 Coumate
  • Irosustat
Molecular Formula
C14H15NO5S
Formula Weight
309.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/ml
SMILES
O=C1C2=C(CCCCC2)C3=CC=C(OS(N)(=O)=O)C=C3O1
InChi Code
InChI=1S/C14H15NO5S/c15-21(17,18)20-9-6-7-11-10-4-2-1-3-5-12(10)14(16)19-13(11)8-9/h6-8H,1-5H2,(H2,15,17,18)
InChi Key
DSLPMJSGSBLWRE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $168

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    10 mg

    $303

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    25 mg

    $527

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    Product Description

    STX-64 is a steroid sulfatase inhibitor (IC50 = 0.008 µM in placental microsomes).1 It also inhibits carbonic anhydrase II (CAII; IC50 = 0.025 µM).2 STX-64 inhibits LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; Item No. 14010) in RAW 264.7 macrophages (IC50s = 85.76 and 0.081 µM, respectively).3 It reduces rat liver steroid sulfatase activity when administered at a dose of 1 mg/kg.1 STX-64 (2 mg/kg) inhibits estrone sulfate-induced uterine growth and reduces the growth of N-nitroso-N-methylurea-induced, estrone sulfate-maintained mammary tumors in ovariectomized rats.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Malini, B., Purohit, A., Ganeshapillai, D., et al. Inhibition of steroid sulphatase activity by tricyclic coumarin sulphamates. J. Steroid Biochem. Mol. Biol. 75(4-5), 253-258 (2000).

    2. Ho, Y.T., Purohit, A., Vicker, N., et al. Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates. Biochem. Biophys. Res. Commun. 305(4), 909-914 (2003).

    3. Jang, H.-L., El-Gamal, M.I., Choi, H.-E., et al. Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE2 productions in RAW 264.7 macrophages. Bioorg. Med. Chem. Lett. 24(2), 571-575 (2014).

    4. Purohit, A., Woo, L.W., Potter, B.V., et al. In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE. Cancer Res. 60(13), 3394-3396 (2000).