STX-64

STX-64 is a steroid sulfatase inhibitor (IC₅₀ = 0.008 µM in placental microsomes).¹ It also inhibits carbonic anhydrase II (CAII; IC₅₀ = 0.025 µM).² STX-64 inhibits LPS-induced production of nitric oxide (NO) and prostaglandin E₂ (PGE₂; Item No. 14010) in RAW 264.7 macrophages (IC₅₀s = 85.76 and 0.081 µM, respectively).³ It reduces rat liver steroid sulfatase activity when administered at a dose of 1 mg/kg.¹ STX-64 (2 mg/kg) inhibits estrone sulfate-induced uterine growth and reduces the growth of N-nitroso-N-methylurea-induced, estrone sulfate-maintained mammary tumors in ovariectomized rats.⁴

WARNING This product is not for human or veterinary use.

1. Malini, B., Purohit, A., Ganeshapillai, D., et al. Inhibition of steroid sulphatase activity by tricyclic coumarin sulphamates. J. Steroid Biochem. Mol. Biol. 75(4-5), 253-258 (2000).

2. Ho, Y.T., Purohit, A., Vicker, N., et al. Inhibition of carbonic anhydrase II by steroidal and non-steroidal sulphamates. Biochem. Biophys. Res. Commun. 305(4), 909-914 (2003).

3. Jang, H.-L., El-Gamal, M.I., Choi, H.-E., et al. Synthesis of tricyclic fused coumarin sulfonates and their inhibitory effects on LPS-induced nitric oxide and PGE₂ productions in RAW 264.7 macrophages. Bioorg. Med. Chem. Lett. 24(2), 571-575 (2014).

4. Purohit, A., Woo, L.W., Potter, B.V., et al. In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 COUMATE. Cancer Res. 60(13), 3394-3396 (2000).