A nitric oxide donor and an active metabolite of isosorbide dinitrate
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Isosorbide-2-nitrate

Item No. 9003732

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,4:3,6-dianhydro-D-glucitol, 2-nitrate
CAS Number
16106-20-0
Synonyms
  • IS 2-MN
  • Isosorbide 2-mononitrate
Molecular Formula
C6H9NO6
Formula Weight
191.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleMethanol: Soluble
SMILES
O[C@H](CO1)[C@]2([H])[C@@]1([H])[C@@H](O[N+]([O-])=O)CO2
InChi Code
InChI=1S/C6H9NO6/c8-3-1-11-6-4(13-7(9)10)2-12-5(3)6/h3-6,8H,1-2H2/t3-,4?,5-,6-/m1/s1
InChi Key
YWXYYJSYQOXTPL-UEPKTDPCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $75

    Add

    5 mg

    $187

    Add

    10 mg

    $300

    Add

    25 mg

    $655

    Add
    Product Description

    Isosorbide-2-nitrate is a nitric oxide (NO) donor and an active metabolite of isosorbide dinitrate (Item No. 23990).1,2 It inhibits potassium chloride- or angiotensin II-induced contraction of rabbit aortic strips and vasopressin-induced coronary spasm in isolated rabbit hearts when used at concentrations of 100 and 1,000 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Raddino, R., Caretta, G., Bonadei, I., et al. Differences between nitrates: Role of isosorbide 2-mononitrate. J. Cardiovasc. Med. (Hagerstown) 11(7), 486-492 (2010).

    2. Patel, B.D., Pulakundam, N., Gadekar, A.R., et al. Development and validation of a chiral LC-ESI-MS/MS method for simultaneous determination of the enantiomeric metabolites isosorbide 2-mononitrate and isosorbide 5-mononitrate of isosorbide dinitrate in rat and human plasma. J. Pharm. Biomed. Anal. 174, 396-405 (2019).