An inhibitor of acid ceramidase
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SABRAC

Item No. 9003925

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-bromo-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-acetamide
CAS Number
886212-98-2
Molecular Formula
C20H40BrNO3
Formula Weight
422.4
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Soluble
SMILES
BrCC(N[C@@H](CO)[C@@H](CCCCCCCCCCCCCCC)O)=O
InChi Code
InChI=1S/C20H40BrNO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(24)18(17-23)22-20(25)16-21/h18-19,23-24H,2-17H2,1H3,(H,22,25)/t18-,19+/m0/s1
InChi Key
KXLZSKTVZMRRCY-RBUKOAKNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $70

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    5 mg

    $222

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    10 mg

    $376

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    Product Description

    SABRAC is an inhibitor of acid ceramidase (IC50 = 52 nM).1 It is selective for acid ceramidase over neutral ceramidase and the cysteine protease papain at 3 µM. SABRAC inhibits acid ceramidase in PC3 MC metastatic prostate cancer cells (IC50 = <1 µM), as well as induces accumulation of ceramides in the same cells. It completely inhibits anchorage-independent colony formation but does not induce cytotoxicity in PC3 MC cells when used at a concentration of 5 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Camacho, L., Meca-Cortés, O., Abad, J.L., et al. Acid ceramidase as a therapeutic target in metastatic prostate cancer. J. Lipid Res. 54(5), 1207-1220 (2013).

    Product Citations

    Nobumoto, W., Naganuma, T., Nozaka, N., et al. Acid ceramidase ASAH1 is a key regulator of epidermal ceramide levels and composition. The Journal of Biological Chemisty 302(3), 111178 (2026).