An inhibitor of acid ceramidase
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SACLAC

Item No. 9003926

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-chloro-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-acetamide
CAS Number
2248703-42-4
Molecular Formula
C20H40ClNO3
Formula Weight
378.0
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Soluble
SMILES
ClCC(N[C@@H](CO)[C@@H](CCCCCCCCCCCCCCC)O)=O
InChi Code
InChI=1S/C20H40ClNO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(24)18(17-23)22-20(25)16-21/h18-19,23-24H,2-17H2,1H3,(H,22,25)/t18-,19+/m0/s1
InChi Key
XDHVKWVHTCINMB-RBUKOAKNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $70

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    5 mg

    $222

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    10 mg

    $376

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    Product Description

    SACLAC is an irreversible inhibitor of acid ceramidase (Ki = 97.1 nM) and a derivative of the acid ceramidase inhibitor SABRAC (Item No. 9003925).1 It decreases levels of sphingosine-1-phosphate (S1P) and increases total ceramide levels in OCI-AML-2 acute myeloid leukemia (AML) cells when used at a concentration of 2.5 µM.2 SACLAC (10 and 20 µM) induces apoptosis in primary AML cells. It reduces leukemic burden in MV4-11 and U937 AML mouse xenograft models when administered at a dose of 5 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ordóñez, Y.F., Abad, J.L., Aseeri, M., et al. Activity-based imaging of acid ceramidase in living cells. J. Am. Chem. Soc. 141(19), 7736-7742 (2019).

    2. Pearson, J.M., Tan, S.-F., Sharma, A., et al. Ceramide analogue SACLAC modulates sphingolipid levels and MCL-1 splicing to induce apoptosis in acute myeloid leukemia. Mol. Cancer Res. 18(3), 352-363 (2020).