A P2RY8 ligand
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S-Geranylgeranyl-L-glutathione

Item No. 9004116

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N5-((R)-1-((carboxymethyl)amino)-1-oxo-3-(((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraen-1-yl)thio)propan-2-yl)-L-glutamine
CAS Number
2364639-42-7
Synonyms
  • GGG
Molecular Formula
C30H49N3O6S
Formula Weight
579.8
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 1 mg/ml (warmed, vortexed)
SMILES
OC([C@@H](N)CCC(N[C@H](C(NCC(O)=O)=O)CSC/C=C(C)/CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)=O)=O
InChi Code
InChI=1S/C30H49N3O6S/c1-21(2)9-6-10-22(3)11-7-12-23(4)13-8-14-24(5)17-18-40-20-26(29(37)32-19-28(35)36)33-27(34)16-15-25(31)30(38)39/h9,11,13,17,25-26H,6-8,10,12,14-16,18-20,31H2,1-5H3,(H,32,37)(H,33,34)(H,35,36)(H,38,39)/b22-11+,23-13+,24-17+/t25-,26-/m0/s1
InChi Key
BAJIBEVLRWVBAZ-DPRMOSMCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    S-Geranylgeranyl-L-glutathione is a ligand of the orphan G protein-coupled receptor (GPCR) P2RY8.1 It selectively induces internalization of P2RY8 over sphingosine-1-phosphate receptor 2 (S1P2), GPR55, cysteinyl leukotriene receptor 1 (CysLT1 receptor), and CysLT2 receptor at 100 nM. S-Geranylgeranyl-L-glutathione (10 nM) inhibits the migration of P2RY8-expressing WEHI-231 B cell lymphoma cells and isolated human tonsil germinal center B cells induced by chemokine (C-X-C motif) ligand 12 (WEHI-231).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lu, E., Wolfreys, F.D., Muppidi, J.R., et al. S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8. Nature 567(7724), 244-248 (2019).