An internal standard for the quantification of BAY 57-1293
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Unlabeled Version(s)
22129BAY 57-1293
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BAY 57-1293-d4

Item No. 9004311

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[5-(aminosulfonyl)-4-methyl-2-thiazolyl]-N-methyl-4-(2-pyridinyl-d4)-benzeneacetamide
Synonyms
  • Pritelivir-d4
Molecular Formula
C18H14D4N4O3S2
Formula Weight
406.5
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: SolubleDMSO: SolubleMethanol: Soluble
SMILES
O=C(CC1=CC=C(C2=C([2H])C([2H])=C([2H])C([2H])=N2)C=C1)N(C)C3=NC(C)=C(S(N)(=O)=O)S3
InChi Code
InChI=1S/C18H18N4O3S2/c1-12-17(27(19,24)25)26-18(21-12)22(2)16(23)11-13-6-8-14(9-7-13)15-5-3-4-10-20-15/h3-10H,11H2,1-2H3,(H2,19,24,25)/i3D,4D,5D,10D
InChi Key
IVZKZONQVYTCKC-GTRXFJCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

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    Product Description

    BAY 57-1293-d4 is intended for use as an internal standard for the quantification of BAY 57-1293 (Item No. 22129) by GC- or LC-MS. BAY 57-1293 is an orally bioavailable helicase-primase inhibitor.1 It inhibits the ATPase activity of herpes simplex virus (HSV) helicase-primase (IC50 = 30 nM). It inhibits HSV replication in Vero cells (IC50 = 20 nM for both HSV-1 and HSV-2) and is also active against porcine and bovine HSV strains (IC50s = 5 and 0.12 μM, respectively). In vivo, oral administration of BAY 57-1293 is effective against HSV-1 and HSV-2 in a lethal challenge model (ED50 = 0.5 mg/kg in mice and rats) and in a zosteriform spread model, at a dose of 15 mg/kg, in mice and Lewis rats.1,2 It is also effective in a guinea pig model of genital herpes and a mouse model of ocular herpes. BAY 57-1293 reduces levels of amyloid-beta (Aβ) and phosphorylated Tau in HSV-1 infected Vero cells.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kleymann, G., Fischer, R., Betz, U.A., et al. New helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease. Nat. Med. 8(4), 392-398 (2002).

    2. Betz, U.A., Fischer, R., Kleymann, G., et al. Potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor BAY 57-1293. Antimicrob. Agents Chemother. 46(6), 1766-1772 (2002).

    3. Wozniak, M.A., Frost, A.L., and Itzhaki, R.F. The helicase-primase inhibitor BAY 57-1293 reduces the Alzheimer’s disease-related molecules induced by herpes simplex virus type 1. Antiviral Res. 99(3), 401-404 (2013).