An ionizable amphiphilic Janus dendrimer
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IAJD97

Item No. 9004563

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-hydroxyethyl)-1-piperazinebutanoic acid, [3,4,5-tris[(2-ethylhexyl)oxy]phenyl]methyl ester
CAS Number
2857089-36-0
Molecular Formula
C41H74N2O6
Formula Weight
691.0
Purity
≥98%
Formulation (Request formulation change)
A neat oil
Solubility(Learn about Variance in Solubility)
Chloroform: soluble
SMILES
O=C(CCCN1CCN(CC1)CCO)OCC2=CC(OCC(CC)CCCC)=C(C(OCC(CC)CCCC)=C2)OCC(CCCC)CC
InChi Code
InChI=1S/C41H74N2O6/c1-7-13-17-34(10-4)30-46-38-28-37(33-48-40(45)20-16-21-42-22-24-43(25-23-42)26-27-44)29-39(47-31-35(11-5)18-14-8-2)41(38)49-32-36(12-6)19-15-9-3/h28-29,34-36,44H,7-27,30-33H2,1-6H3
InChi Key
BPXZZLSZIMGJNB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 mg

    $110

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    Product Description

    IAJD97 is an ionizable amphiphilic Janus dendrimer (pKa = 6.46) that has been used in the generation of dendrosome nanoparticles (DNPs) for the delivery of mRNA in vivo.1,2 DNPs composed of IAJD97 and encapsulating mRNA encoding luciferase selectively accumulate in the lymph nodes, spleen, and lungs over the liver and heart in mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, D., Atochina-Vasserman, E.N., Maurya, D.S., et al. Targeted delivery of mRNA with one-component ionizable amphiphilic Janus dendrimers. J. Am. Chem. Soc. 143(43), 17975-17982 (2021).

    2. Arshad, M., Atochina-Vasserman, E.N., Chenna, S.S., et al. Accelerated ten-gram-scale synthesis of one-component multifunctional sequence-defined ionizable amphiphilic Janus dendrimer 97. Biomacromolecules 25(10), 6871-6882 (2024).